RAS processing

Stable Identifier
R-HSA-9648002
Type
Pathway
Species
Homo sapiens
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RAS proteins undergo several processing steps during maturation including farnesylation, carboxy-terminal cleavage and carboxymethylation, among others. These steps are required for their membrane localization and function and ultimately for their ability to activate RAF (reviewed in Gysin et al, 2011; Ahearn et al, 2018).

Literature References
PubMed ID Title Journal Year
21779505 Therapeutic strategies for targeting ras proteins

McCormick, F, Salt, M, Young, A, Gysin, S

Genes Cancer 2011
29311131 Posttranslational Modifications of RAS Proteins

Philips, MR, Zhou, M, Ahearn, I

Cold Spring Harb Perspect Med 2018
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GlyCosmos
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