KRAS G12A [plasma membrane]

Stable Identifier
R-HSA-9649088
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
26662311 G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab

Sedivcova, M, Holubec, L, Bartouskova, M, Matejka, VM, Kulhankova, J, Liska, V, Topolcan, O, Finek, J, Mohelnikova-Duchonova, B, Buchler, T, Melichar, B, Bortlicek, Z, Fiala, O

Tumour Biol. 2016
29199977 Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras

Kennedy, MA, Xu, S, Long, BN, Boris, GH, Ni, S, Chen, A

Acta Crystallogr D Struct Biol 2017
30738221 Efficacy of Immune Checkpoint Inhibitors in KRAS-Mutant Non-Small Cell Lung Cancer (NSCLC)

Biemar, J, Garcia, S, Milia, J, Souquet-Bressand, M, Ouafik, L, Chaleat, S, Grangeon, M, Nanni, I, Jeanson, A, Mazieres, J, Tomasini, P, Boucekine, M, Greillier, L, Khobta, N, Mhanna, L, Mascaux, C, Barlesi, F, Brandone, N

J Thorac Oncol 2019
External Reference Information
External Reference
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Participates
Other forms of this molecule
Modified Residues
Name
glycine 12 replaced with L-alanine
Coordinate
12
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-alanine.
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
endometrial cancer DOID:1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
lung cancer DOID:1324
colorectal cancer DOID:9256
pancreatic cancer DOID:1793 malignant neoplasm of tail of pancreas, pancreatic tumor, Ca body of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas, pancreatic neoplasm, malignant tumor of body of pancreas (disorder), Ca tail of pancreas (disorder), malignant neoplasm of head of pancreas, Ca tail of pancreas, malignant tumor of tail of pancreas (disorder), neoplasm of pancreas (disorder), Ca head of pancreas, Ca body of pancreas (disorder)
Cross References
COSMIC
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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