KRAS A146T [plasma membrane]

Stable Identifier
R-HSA-9649623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
30952657 Tissue-Specific Oncogenic Activity of KRASA146T

Brubaker, DK, Yan, W, Ghazi, PC, Strasser, SD, Lu, J, Gygi, SP, Poulin, EJ, Engen, JR, Bera, AK, Joughin, BA, Johnson, CW, Nowak, JA, Lin, YJ, Braun, BS, Huang, TQ, Morales, C, Pérez-Mancera, PA, Gierut, JJ, DeStefanis, RA, Paulo, JA, Westover, KD, Gondi, S, Bogdanova, L, Li, Y, Haigis, KM, Cook, J, Wales, TE, Iacob, RE, Lauffenburger, DA

Cancer Discov 2019
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
initiator methionine:1, chain:1-186, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703.14 KRAS
HGNC:6407 KRAS
KEGG Gene (Homo sapiens):3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
Other Identifiers
0006110070
0007040129
11717962_x_at
11717963_a_at
11717964_a_at
11717965_s_at
16762399
1940_at
204009_PM_s_at
204009_s_at
204010_PM_s_at
204010_s_at
214352_PM_s_at
214352_s_at
231640_PM_at
231640_at
32159_at
3447860
3447862
3447864
3447865
3447866
3447867
3447868
3447869
3447870
3447871
3447872
3447873
3447874
3447879
3447880
3447884
3447886
3845
3958621
7961865
A_23_P306500
A_23_P306507
A_23_P45140
A_33_P3317815
GE61031
GO:0000139
GO:0000165
GO:0000166
GO:0001934
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005622
GO:0005737
GO:0005739
GO:0005741
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0005925
GO:0007010
GO:0007165
GO:0007265
GO:0008283
GO:0008284
GO:0008542
GO:0010628
GO:0012501
GO:0012505
GO:0014009
GO:0016020
GO:0016601
GO:0016787
GO:0019003
GO:0021897
GO:0023052
GO:0030036
GO:0030154
GO:0030857
GO:0031234
GO:0031647
GO:0032228
GO:0035022
GO:0035914
GO:0036211
GO:0038002
GO:0042802
GO:0043226
GO:0043524
GO:0044877
GO:0048169
GO:0048856
GO:0048873
GO:0050877
GO:0050886
GO:0051146
GO:0051402
GO:0060252
GO:0060441
GO:0060509
GO:0098772
HMNXSV003005517
HMNXSV003016084
Hs.184050.0.S1_3p_a_at
Hs.184050.1.A1_3p_a_at
Hs.184050.4.A1_3p_at
ILMN_1652104
ILMN_1728071
M54968_at
PH_hs_0028364
PH_hs_0030345
TC12001314.hg
g4826811_3p_a_at
Participates
as a member of
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS G12C [plasma membrane]
KRAS L19F [plasma membrane]
KRAS G12D [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS V14I [plasma membrane]
KRAS G12V [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G13D [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G60R [plasma membrane]
KRAS D33E [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS G60V [plasma membrane]
KRAS G60D [plasma membrane]
KRAS E63K [plasma membrane]
KRAS A59T [plasma membrane]
KRAS [plasma membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
S-Farn-proKRAS [endoplasmic reticulum membrane]
proKRAS [cytosol]
Modified Residues
Name
L-alanine 146 replaced with L-threonine
Coordinate
146
PsiMod
L-alanine removal [MOD:01631]
A protein modification that effectively removes or replaces an L-alanine.
L-threonine residue [MOD:00026]
A protein modification that effectively converts a source amino acid residue to L-threonine.
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
hematologic cancer DOID:2531 hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
PRO
PDB
7ACF, 6O46, 5WHE, 6E6F, 6GJ5, 6OIM, 4Q03, 4LYF, 4WA7, 6FA2, 6YXW, 1D8E, 5KYK, 6EPM, 1N4S, 6GJ6, 6V5L, 5OCT, 5YY1, 7F0W, 6MNX, 6CC9, 6H47, 6GQY, 7A47, 6PGP, 6H46, 6WS2, 6GOF, 5UFE, 5VP7, 6ASE, 6T5U, 6EPO, 7RSE, 6QUV, 5US4, 6BOF, 4M1W, 3GFT, 7A1Y, 6FA1, 5OCG, 7NY8, 6JTN, 5F2E, 7EW9, 6GOD, 1D8D, 6XGV, 6N2J, 5TB5, 7ACA, 7RT1, 6GOG, 6ZLI, 6GQX, 6QUX, 4QL3, 6CCX, 7ACQ, 6ARK, 5O2S, 7RT2, 6MBT, 7A1X, 6XHA, 7EWB, 7T47, 6WS4, 6XGU, 4LRW, 1N4R, 6OB2, 5WPM, 6QUW, 5V9U, 7EYX, 6P0Z, 4EPT, 7RT3, 1N4Q, 6GJ7, 4M21, 4LYH, 5UFQ, 4EPX, 6W4E, 6USX, 6PTW, 6CCH, 6WGN, 6V6F, 1KZO, 7KMR, 4M1Y, 7RT4, 6P8X, 6YR8, 6T5V, 4LV6, 6GOE, 7RP3, 4L8G, 5UQW, 4TQA, 5XCO, 7RP2, 4M1T, 7LC1, 6O4Y, 6CU6, 6P8Y, 6ZL5, 6M9W, 4LDJ, 5VPY, 5V9O, 6O51, 7C40, 6XHB, 5MLA, 7KFZ, 4EPW, 6GQT, 5VQ8, 6JTP, 5UK9, 6MS9, 6O4Z, 6GJ8, 4NMM, 6P8W, 5WHA, 6VC8, 5OCO, 6JTO, 7LGI, 7RP4, 4M1S, 5V71, 5YXZ, 6EPL, 6B0Y, 7RPZ, 6PQ3, 7MDP, 4LYJ, 5VQ6, 1N4P, 5VQ1, 4DSN, 6TAM, 6GQW, 5V6S, 6E6G, 7C41, 6MQN, 5VPZ, 5VPI, 5VQ2, 7LC2, 6FA4, 7Q9U, 5TAR, 6EPN, 6FA3, 4PZZ, 5WLB, 6BP1, 5USJ, 5WHB, 4Q02, 5VBM, 4M22, 5WHD, 6USZ, 1KZP, 7ACH, 7RSC, 7A1W, 6VJJ, 4Q01, 6ASA, 7LZ5, 6PTS, 4DSO, 6UT0, 6EPP, 4OBE, 4EPR, 5VQ0, 5V6V, 6QUU, 7ROV, 6MBU, 4EPY, 6MQG, 5V9L, 4LUC, 6O53, 4LPK, 4TQ9, 5MLB, 6OB3, 6PGO, 7RT5, 4EPV, 6N2K, 6GOM, 4M1O, 6T5B, 5W22, 6W4F, 4PZY, 6MTA, 6O36, 6TAN, 7EWA, 6P8Z, 5O2T, 6F76, 6B0V, 6V65, 6MBQ
COSMIC
HPA
GeneCards
Ensembl
Pharos - Targets
Orphanet
Interactors (10)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P15056 BRAF  20 0.483 3
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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