KRAS A146T [plasma membrane]

Stable Identifier
R-HSA-9649623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
30952657 Tissue-Specific Oncogenic Activity of KRASA146T

Brubaker, DK, Yan, W, Ghazi, PC, Strasser, SD, Lu, J, Gygi, SP, Poulin, EJ, Engen, JR, Bera, AK, Joughin, BA, Johnson, CW, Nowak, JA, Lin, YJ, Braun, BS, Huang, TQ, Morales, C, Pérez-Mancera, PA, Gierut, JJ, DeStefanis, RA, Paulo, JA, Westover, KD, Gondi, S, Bogdanova, L, Li, Y, Haigis, KM, Cook, J, Wales, TE, Iacob, RE, Lauffenburger, DA

Cancer Discov 2019
Participates
Other forms of this molecule
Modified Residues
Name
L-alanine 146 replaced with L-threonine
Coordinate
146
PsiMod
A protein modification that effectively removes or replaces an L-alanine.
A protein modification that effectively converts a source amino acid residue to L-threonine.
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
hematologic cancer DOID:2531 hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
Cross References
Guide to Pharmacology - Targets
OpenTargets
ZINC - Substances
ZINC target
PRO
PDB
7R0M, 7RT2, 7SCX, 2MSE, 8VRA, 6PGO, 7EYX, 6GOD, 8G9Q, 7T1F, 6QUX, 6GOM, 4M1O, 7OK3, 5V6S, 6FA2, 8DGT, 4EPT, 7O70, 1N4Q, 6YXW, 5WHA, 5MLA, 6N2K, 6MTA, 7LZ5, 7KFZ, 5UFQ, 6GJ6, 7LC2, 7YV1, 8T71, 5UQW, 9BG1, 4QL3, 8TXJ, 6MQN, 5UK9, 6BOF, 6P8W, 4OBE, 8B78, 5OCT, 6MBQ, 8QW7, 7MQU, 3GFT, 8X6R, 8TBJ, 4EPY, 6P0Z, 4M1S, 6PGP, 6QUV, 5XCO, 7LGI, 8TXE, 4Q02, 5US4, 8FMK, 8WTE, 4LV6, 6M9W, 1N4R, 8DGS, 8AFC, 6F76, 7ACA, 7OO7, 8AZX, 1KZP, 5V9U, 7TLE, 6EPN, 6V6F, 8TY9, 6WGN, 7YCE, 8AZZ, 4TQ9, 1D8E, 8G4H, 8S8C, 7SCW, 8PI0, 6MBT, 4LRW, 5UFE, 4WA7, 4EPR, 4LPK, 5YY1, 1D8D, 4EPX, 6GOE, 7U8H, 8G9P, 6GQW, 4Q01, 7EW9, 6MQG, 6O51, 8G47, 6EPL, 8DNI, 8CPR, 1N4S, 8B69, 1KZO, 9AX6, 4LDJ, 4NMM, 6OB2, 8QVU, 6BP1, 6O36, 6WS4, 8I5E, 6O4Y, 7NY8, 6VC8, 8AZY, 7STF, 7RT1, 7C41, 7RP4, 6E6G, 6PTW, 6ZLI, 7W5R, 6V5L, 8AQ5, 5OCG, 6JTP, 6ZL5, 6ASA, 8I5C, 5O2S, 8TBM, 6GQT, 7VVB, 8T4V, 5VPI, 6W4E, 8TXG, 8CX5, 7TLK, 8G42, 6JTN, 6XHB, 8T74, 8ONV, 8F0M, 8I5D, 6FA3, 5WHD, 8AZR, 6EPO, 6T5B, 5WLB, 7A47, 8TBN, 5VPY, 8DVG, 5W22, 7RP3, 4PZZ, 8QW6, 7ACH, 8AFB, 8JHL, 8STN, 6GJ7, 5V6V, 2MSC, 4M1W, 8WUL, 7RPZ, 8TBL, 6QUW, 8EER, 6P8Z, 4EPW, 8FMJ, 5TB5, 8JJS, 8BE3, 6WS2, 8EIE, 6O4Z, 8VRB, 6JTO, 7F0W, 6MS9, 7R0Q, 8EBZ, 8BLR, 6CCX, 6E6F, 6FA4, 8UDR, 8UN4, 8BE4, 4DSO, 8T73, 4LYJ, 8TXH, 8ECR, 6V65, 7C40, 8VR9, 5VPZ, 7RT4, 7A1Y, 5VQ2, 4Q03, 8STM, 4PZY, 6USZ, 9BFY, 8AQ7, 5KYK, 6B0Y, 6ARK, 6P8X, 8JGD, 7RT5, 6W4F, 8FMI, 5WHE, 6FA1, 6XHA, 6VJJ, 8DNK, 6XGU, 6PQ3, 4LYH, 8UN5, 8T75, 7ACQ, 8UN3, 7LC1, 6EPP, 8TY2, 5WPM, 8G4F, 6GOF, 5VQ0, 8TBF, 4M22, 7A1W, 6QUU, 7RSC, 5VBM, 6H46, 5V9O, 7RP2, 6GJ8, 7KMR, 7OK4, 6YR8, 6UT0, 6CCH, 8QU8, 2MSD, 5O2T, 5WHB, 7YCC, 4LUC, 7EWA, 5V71, 7ROV, 1N4P, 6XGV, 6N2J, 6ASE, 8DNJ, 6TAM, 6GJ5, 4L8G, 6PTS, 5V9L, 7KYZ, 4DSN, 7EWB, 7MDP, 6O46, 8EZG, 8TXK, 5OCO, 6MBU, 5VP7, 8TBH, 6GQX, 5VQ1, 5VQ8, 7RT3, 7A1X, 8R7X, 6H47, 7ACF, 5YXZ, 8AFD, 6T5U, 6B0V, 6P8Y, 4M1T, 5VQ6, 7T47, 8TBK, 7RSE, 8EPW, 4EPV, 8BE5, 6MNX, 7YUZ, 8B6I, 7R0N, 5MLB, 7TLG, 5TAR, 6USX, 6TAN, 8T72, 6OIM, 7Q9U, 8AZV, 5F2E, 8TVK, 6OB3, 6EPM, 8TY8, 6CU6, 4LYF, 5USJ, 6O53, 6CC9, 6GOG, 8B00, 4M21, 4TQA, 6GQY, 8EDY, 8QUG, 4M1Y, 6T5V, 8R7W
COSMIC
GeneCards
Pharos - Targets
Orphanet
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
Cite Us!