KRAS A146T [plasma membrane]

Stable Identifier
R-HSA-9649623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
30952657 Tissue-Specific Oncogenic Activity of KRASA146T

Brubaker, DK, Yan, W, Ghazi, PC, Strasser, SD, Lu, J, Gygi, SP, Poulin, EJ, Engen, JR, Bera, AK, Joughin, BA, Johnson, CW, Nowak, JA, Lin, YJ, Braun, BS, Huang, TQ, Morales, C, Pérez-Mancera, PA, Gierut, JJ, DeStefanis, RA, Paulo, JA, Westover, KD, Gondi, S, Bogdanova, L, Li, Y, Haigis, KM, Cook, J, Wales, TE, Iacob, RE, Lauffenburger, DA

Cancer Discov 2019
External Reference Information
External Reference
UniProt:P01116 KRAS
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:3845 KRAS
COSMIC (genes):KRAS KRAS
CTD Gene:3845 KRAS
dbSNP Gene:3845 KRAS
ENSEMBL:ENSG00000133703 KRAS
HGNC:6407 KRAS
KEGG:hsa:3845 KRAS
Monarch:3845 KRAS
NCBI Gene:3845 KRAS
OMIM:190070 KRAS
UCSC:P01116 KRAS
Reference Transcript
Participates
as a member of
Other forms of this molecule
S-Farn-Me-PalmS KRAS [plasma membrane]
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
KRAS K147E [plasma membrane]
KRAS K147T [plasma membrane]
KRAS V14G [plasma membrane]
KRAS K147N [plasma membrane]
KRAS A146V [plasma membrane]
KRAS A146S [plasma membrane]
KRAS A146P [plasma membrane]
KRAS P34R [plasma membrane]
KRAS P34L [plasma membrane]
KRAS G12A [plasma membrane]
KRAS G12R [plasma membrane]
KRAS G13V [plasma membrane]
KRAS G13S [plasma membrane]
KRAS G13C [plasma membrane]
KRAS G13R [plasma membrane]
KRAS G13A [plasma membrane]
KRAS K5N [plasma membrane]
KRAS G12S [plasma membrane]
KRAS Q61L [plasma membrane]
KRAS Q61K [plasma membrane]
KRAS Q61R [plasma membrane]
KRAS F156L [plasma membrane]
KRAS G12C [plasma membrane]
KRAS [plasma membrane]
S-Farn-KRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
S-Farn-proKRAS [endoplasmic reticulum membrane]
proKRAS [cytosol]
KRAS A59T [plasma membrane]
KRAS E63K [plasma membrane]
KRAS G60D [plasma membrane]
KRAS G60V [plasma membrane]
KRAS Q22K [plasma membrane]
KRAS D33E [plasma membrane]
KRAS G60R [plasma membrane]
KRAS T58I [plasma membrane]
KRAS G13D [plasma membrane]
KRAS D153V [plasma membrane]
KRAS G12V [plasma membrane]
KRAS V14I [plasma membrane]
KRAS Q61H [plasma membrane]
KRAS Q22R [plasma membrane]
KRAS K117N [plasma membrane]
KRAS Q22E [plasma membrane]
KRAS G12D [plasma membrane]
KRAS L19F [plasma membrane]
Modified Residues
Name
L-alanine 146 replaced with L-threonine
Coordinate
146
PsiMod
L-alanine removal [MOD:01631]
A protein modification that effectively removes or replaces an L-alanine.
L-threonine residue [MOD:00026]
A protein modification that effectively converts a source amino acid residue to L-threonine.
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
hematologic cancer DOID:2531 hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC target
PRO
PDB
7R0M, 7RT2, 7SCX, 2MSE, 8VRA, 6PGO, 7EYX, 6GOD, 8G9Q, 7T1F, 6QUX, 6GOM, 4M1O, 7OK3, 5V6S, 6FA2, 8DGT, 4EPT, 7O70, 1N4Q, 6YXW, 5WHA, 5MLA, 6N2K, 6MTA, 7LZ5, 7KFZ, 5UFQ, 6GJ6, 7LC2, 7YV1, 8T71, 5UQW, 9BG1, 4QL3, 8TXJ, 6MQN, 5UK9, 6BOF, 6P8W, 4OBE, 8B78, 5OCT, 6MBQ, 8QW7, 7MQU, 3GFT, 8X6R, 8TBJ, 4EPY, 6P0Z, 4M1S, 6PGP, 6QUV, 5XCO, 7LGI, 8TXE, 4Q02, 5US4, 8FMK, 8WTE, 4LV6, 6M9W, 1N4R, 8DGS, 8AFC, 6F76, 7ACA, 7OO7, 8AZX, 1KZP, 5V9U, 7TLE, 6EPN, 6V6F, 8TY9, 6WGN, 7YCE, 8AZZ, 4TQ9, 1D8E, 8G4H, 8S8C, 7SCW, 8PI0, 6MBT, 4LRW, 5UFE, 4WA7, 4EPR, 4LPK, 5YY1, 1D8D, 4EPX, 6GOE, 7U8H, 8G9P, 6GQW, 4Q01, 7EW9, 6MQG, 6O51, 8G47, 6EPL, 8DNI, 8CPR, 1N4S, 8B69, 1KZO, 9AX6, 4LDJ, 4NMM, 6OB2, 8QVU, 6BP1, 6O36, 6WS4, 8I5E, 6O4Y, 7NY8, 6VC8, 8AZY, 7STF, 7RT1, 7C41, 7RP4, 6E6G, 6PTW, 6ZLI, 7W5R, 6V5L, 8AQ5, 5OCG, 6JTP, 6ZL5, 6ASA, 8I5C, 5O2S, 8TBM, 6GQT, 7VVB, 8T4V, 5VPI, 6W4E, 8TXG, 8CX5, 7TLK, 8G42, 6JTN, 6XHB, 8T74, 8ONV, 8F0M, 8I5D, 6FA3, 5WHD, 8AZR, 6EPO, 6T5B, 5WLB, 7A47, 8TBN, 5VPY, 8DVG, 5W22, 7RP3, 4PZZ, 8QW6, 7ACH, 8AFB, 8JHL, 8STN, 6GJ7, 5V6V, 2MSC, 4M1W, 8WUL, 7RPZ, 8TBL, 6QUW, 8EER, 6P8Z, 4EPW, 8FMJ, 5TB5, 8JJS, 8BE3, 6WS2, 8EIE, 6O4Z, 8VRB, 6JTO, 7F0W, 6MS9, 7R0Q, 8EBZ, 8BLR, 6CCX, 6E6F, 6FA4, 8UDR, 8UN4, 8BE4, 4DSO, 8T73, 4LYJ, 8TXH, 8ECR, 6V65, 7C40, 8VR9, 5VPZ, 7RT4, 7A1Y, 5VQ2, 4Q03, 8STM, 4PZY, 6USZ, 9BFY, 8AQ7, 5KYK, 6B0Y, 6ARK, 6P8X, 8JGD, 7RT5, 6W4F, 8FMI, 5WHE, 6FA1, 6XHA, 6VJJ, 8DNK, 6XGU, 6PQ3, 4LYH, 8UN5, 8T75, 7ACQ, 8UN3, 7LC1, 6EPP, 8TY2, 5WPM, 8G4F, 6GOF, 5VQ0, 8TBF, 4M22, 7A1W, 6QUU, 7RSC, 5VBM, 6H46, 5V9O, 7RP2, 6GJ8, 7KMR, 7OK4, 6YR8, 6UT0, 6CCH, 8QU8, 2MSD, 5O2T, 5WHB, 7YCC, 4LUC, 7EWA, 5V71, 7ROV, 1N4P, 6XGV, 6N2J, 6ASE, 8DNJ, 6TAM, 6GJ5, 4L8G, 6PTS, 5V9L, 7KYZ, 4DSN, 7EWB, 7MDP, 6O46, 8EZG, 8TXK, 5OCO, 6MBU, 5VP7, 8TBH, 6GQX, 5VQ1, 5VQ8, 7RT3, 7A1X, 8R7X, 6H47, 7ACF, 5YXZ, 8AFD, 6T5U, 6B0V, 6P8Y, 4M1T, 5VQ6, 7T47, 8TBK, 7RSE, 8EPW, 4EPV, 8BE5, 6MNX, 7YUZ, 8B6I, 7R0N, 5MLB, 7TLG, 5TAR, 6USX, 6TAN, 8T72, 6OIM, 7Q9U, 8AZV, 5F2E, 8TVK, 6OB3, 6EPM, 8TY8, 6CU6, 4LYF, 5USJ, 6O53, 6CC9, 6GOG, 8B00, 4M21, 4TQA, 6GQY, 8EDY, 8QUG, 4M1Y, 6T5V, 8R7W
COSMIC
GeneCards
HPA
Pharos - Targets
Orphanet
HMDB Protein
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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