Translation of DDIT3

Stable Identifier
R-HSA-9650722
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Translation of DDIT3
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The DDIT3 mRNA is translated to yield DDIT3 (CHOP) protein (Jousse et al. 2001, and inferred from the mouse homolog), which is then imported into the nucleus. The mRNA of DDIT3 contains an upstream ORF (uORF) which has a start codon in an unfavorable context (Jousse et al. 2001, and inferred from the mouse homolog), resulting in low expression of the downstream DDIT3 coding region. When EIF2S1 (eIF2-alpha) is phosphorylated in response to stress, translation of the uORF is suppressed and translation of DDIT3 is increased (inferred from the mouse homolog).
Literature References
PubMed ID Title Journal Year
11691921 Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

Ferrara, M, Carraro, V, Ron, D, Urano, F, Bruhat, A, Fafournoux, P, Jousse, C

Nucleic Acids Res. 2001
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
Inferred From
Translation of Ddit3 (Mus musculus)
Authored
May, B  (2019-06-15)
Reviewed
Staschke, KA  (2019-11-20)
Chen, JJ  (2019-10-22)
Bruhat, A  (2019-09-15)
Created
May, B  (2019-06-22)
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