KRAS K147E [plasma membrane]

Stable Identifier
R-HSA-9651169
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
27149842 Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

Cao, Y, Mima, K, Ogino, S, Meyerhardt, JA, Qian, ZR, Amin-Mansour, A, Rosenberg, M, Fuchs, CS, Inamura, K, Bahl, S, Stewart, C, Nowak, JA, Mu, XJ, Van Allen, EM, Garraway, LA, Gabriel, SB, Ng, K, Nishihara, R, Lander, ES, Cohen, O, Nosho, K, Sukawa, Y, Yamauchi, M, Giovannucci, EL, Giannakis, M, Chan, AT, Wu, CJ, Shukla, SA, Getz, G, Lawrence, MS

Cell Rep 2016
23059812 Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes

Cirstea, IC, Ahmadian, MR, Zhang, SC, Piekorz, RP, Zenker, M, Dvorsky, R, Gremer, L

Hum. Mol. Genet. 2013
External Reference Information
External Reference
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Participates
Other forms of this molecule
Modified Residues
Name
L-lysine 147 replaced with L-glutamic acid
Coordinate
147
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
A protein modification that effectively removes or replaces an L-lysine.
Disease
Name Identifier Synonyms
cardiofaciocutaneous syndrome DOID:0060233 CFC syndrome, cardio-facial-cutaneous syndrome
colorectal cancer DOID:9256
Cross References
COSMIC
ClinGen
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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