KRAS Q22R [plasma membrane]

Stable Identifier
R-HSA-9651367
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20949621 Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

Cirstea, IC, Ahmadian, MR, Merbitz-Zahradnik, T, Zenker, M, Dvorsky, R, Gremer, L, Wittinghofer, A, Kratz, CP

Hum. Mutat. 2011
External Reference Information
External Reference
Gene Names
KRAS, KRAS2, RASK2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Participates
Other forms of this molecule
Modified Residues
Name
L-glutamine 22 replaced with L-arginine
Coordinate
22
PsiMod
A protein modification that effectively removes or replaces an L-glutamine.
A protein modification that effectively converts a source amino acid residue to an L-arginine.
Disease
Name Identifier Synonyms
colorectal cancer DOID:9256
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
Cross References
COSMIC
ClinGen
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04049 RAF1  20 0.695 6
 UniProt:Q99755 PIP5K1A  1 0.661 9
 UniProt:P15056 BRAF  20 0.615 4
 UniProt:Q96II5 Q96II5      0.556 3
 UniProt:P50749 RASF2      0.544 2
 UniProt:P61586 RHOA  6 0.519 2
 UniProt:O75915 ARL6IP5  1 0.519 2
 UniProt:P10398 ARAF  4 0.483 2
 UniProt:P28288 ABCD3  2 0.483 2
 UniProt:P01111 NRAS  20 0.483 2
 UniProt:Q7KZI7 MARK2      0.483 2
 UniProt:Q9UQB8 BAIAP2  1 0.483 2
 ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE      0.462 2
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