Reactome | MAP2K2 F57C [cytosol]

MAP2K2 F57C [cytosol]

Stable Identifier

R-HSA-9652073

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MEK2, Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2), Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by MAP2K mutants (Homo sapiens)
      - MAP2K mutants constitutively phosphorylate MAPKs (Homo sapiens)
        
        MAP2K1 and MAP2K2 mutants [cytosol] (Homo sapiens)
        
        MAP2K2 F57C dimer [cytosol] (Homo sapiens)
        
        MAP2K2 F57C [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
18413255	Biochemical characterization of novel germline BRAF and MEK mutations in cardio-facio-cutaneous syndrome Rodriguez-Viciana, P, Rauen, KA	Meth. Enzymol.	2008

External Reference Information

External Reference

UniProt:P36507 MAP2K2

Gene Names

MAP2K2, MEK2, MKK2, PRKMK2

Chain

chain:1-400

Reference Genes

BioGPS Gene:5605 MAP2K2

COSMIC (genes):MAP2K2 MAP2K2

CTD Gene:5605 MAP2K2

dbSNP Gene:5605 MAP2K2

ENSEMBL:ENSG00000126934 MAP2K2

ENSEMBL_homo_sapiens_GENE:ENSG00000126934.15 MAP2K2

HGNC:6842 MAP2K2

KEGG Gene (Homo sapiens):5605 MAP2K2

Monarch:5605 MAP2K2

NCBI Gene:5605 MAP2K2

OMIM:601263 MAP2K2

UCSC:P36507 MAP2K2

Reference Transcript

RefSeq:NM_030662.3 MAP2K2

Other Identifiers

1131_at

11716318_x_at

202424_PM_at

202424_at

213490_PM_s_at

213490_s_at

3023305

3023308

3023309

3023310

3846639

3846640

3846643

3846645

3846646

3846650

3846652

3846653

3846654

3846659

3846660

3846663

3846664

3846665

3846666

5605

8032761

GE57609

GO:0000165

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004712

GO:0004713

GO:0005078

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005777

GO:0005778

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005911

GO:0005925

GO:0006351

GO:0006355

GO:0006468

GO:0007507

GO:0009898

GO:0010628

GO:0014044

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030165

GO:0030878

GO:0031410

GO:0032872

GO:0036211

GO:0036289

GO:0038133

GO:0042552

GO:0043226

GO:0043410

GO:0043539

GO:0045893

GO:0046872

GO:0048009

GO:0048471

GO:0048538

GO:0048679

GO:0048856

GO:0048870

GO:0050772

GO:0060090

GO:0060324

GO:0060425

GO:0060440

GO:0060502

GO:0070371

GO:0071902

GO:0090170

GO:0097110

GO:0098772

GO:0106310

GO:0140096

GO:2000147

GO:2000641

Hs.72241.1.S1_3p_a_at

ILMN_1657968

L11285_at

PH_hs_0029886

TC19001058.hg

g13489053_3p_at

g13489053_3p_x_at

Participates

as a component of

MAP2K2 F57C dimer [cytosol] (Homo sapiens)

Other forms of this molecule

MAP2K2(1-10) [cytosol]

MAP2K2(11-400) [cytosol]

MAP2K2 C125S [cytosol]

MAP2K2 P128Q [cytosol]

MAP2K2 V35M [cytosol]

MAP2K2 Y134C [cytosol]

p-S222,S226-MAP2K2 [cytosol]

MAP2K2 [cytosol]

p-S,T-MAP2K2 [cytosol]

MAP2K2 N126D [cytosol]

MAP2K2 L46F [cytosol]

Modified Residues

Name

L-phenylalanine 57 replaced with L-cysteine

Coordinate

PsiMod

L-phenylalanine removal [MOD:01644]

A protein modification that effectively removes or replaces an L-phenylalanine.

L-cysteine residue [MOD:00014]

A protein modification that effectively converts a source amino acid residue to an L-cysteine.

Disease

Name	Identifier	Synonyms
cardiofaciocutaneous syndrome	DOID:0060233	CFC syndrome, cardio-facial-cutaneous syndrome
melanoma	DOID:1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma

Cross References

RefSeq

NP_109587.1

ZINC - World Drugs

MP2K2_HUMAN

Guide to Pharmacology - Targets

2063

ClinGen

CA279958

OpenTargets

ENSG00000126934

ZINC - FDA approved

MP2K2_HUMAN

ZINC - Substances

MP2K2_HUMAN

ZINC target

P36507

ZINC - Biogenic

MP2K2_HUMAN

PRO

P36507

PDB

4H3Q, 1S9I

ZINC - Investigational

MP2K2_HUMAN

COSMIC

COSV53562150

GeneCards

P36507

HPA

ENSG00000126934-MAP2K2

Ensembl

ENSP00000262948, ENST00000262948, ENSG00000126934

Pharos - Targets

P36507

ZINC - Predictions - Purchasable

MP2K2_HUMAN

Orphanet

16378

HMDB Protein

HMDBP09528

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.91	10
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.886	12
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.85	7
UniProt:Q8IVT5 KSR1	5	p-S311,S406 KSR1 [cytosol] (R-HSA-5672654) KSR1 [cytosol] (R-HSA-5672587) p-S311 KSR1 [cytosol] (R-HSA-5672652) p-S311,Y602 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y602 KSR1 [cytosol] (R-HSA-5672656)	0.798	10
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.725	5
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.725	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.725	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.671	5
UniProt:P68366 TUBA4A	9	TUBA4A [cytosol] (R-HSA-191694) TUBA4A [axonemal microtubule] (R-HSA-5610443) TUBA4A [extracellular region] (R-HSA-350734) Polyglutamyl-TUBA4A [cytosol] (R-HSA-8867386) L-isoglutamyl polyglycyl-TUBA4A [cytosol] (R-HSA-8867378) TUBA4A unfolded [cytosol] (R-HSA-392771) TUBA4A folding intermediate [cytosol] (R-HSA-392800) Ac K40 TUBA4A [axonemal microtubule] (R-HSA-5624859) AcK-TUBA4A [cytosol] (R-HSA-5618318)	0.643	4
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.643	9
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.643	5
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.643	5
UniProt:Q96II5 Q96II5			0.601	4
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:P00540 MOS			0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.553	2
UniProt:Q12959 DLG1	4	DLG1 [cytosol] (R-HSA-416332) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [plasma membrane] (R-HSA-375977)	0.543	10
UniProt:P32970 CD70	1	CD70 [plasma membrane] (R-HSA-5667139)	0.527	2
UniProt:Q58FG1 HS904			0.527	3
UniProt:Q58FG0 HS905			0.527	3
UniProt:Q58FF6 H90B4			0.527	3
UniProt:P04439 HLA-A	9	K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100)	0.527	2
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.527	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.527	3
UniProt:Q9BQE3 TUBA1C	9	AcK-TUBA1C [cytosol] (R-HSA-5618314) Ac K40 TUBA1C [axonemal microtubule] (R-HSA-5624856) TUBA1C folding intermediate [cytosol] (R-HSA-392798) TUBA1C unfolded [cytosol] (R-HSA-392772) L-isoglutamyl polyglycyl-TUBA1C [cytosol] (R-HSA-8867405) Polyglutamyl-TUBA1C [cytosol] (R-HSA-8867401) TUBA1C(1-448) [cytosol] (R-HSA-8955579) TUBA1C [axonemal microtubule] (R-HSA-5610439) TUBA1C [cytosol] (R-HSA-190590)	0.527	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.527	3
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.527	3
UniProt:Q61097	5	phospho-p-S311,S406 KSR1 [cytosol] (R-MMU-5672654) KSR1 [cytosol] (R-MMU-5672587) phospho-p-S311 KSR1 [cytosol] (R-MMU-5672652) phospho-p-S311,Y602 KSR1 [plasma membrane] (R-MMU-5672659) phospho-p-S311,Y602 KSR1 [cytosol] (R-MMU-5672656)	0.508	2
UniProt:P06929 VE6			0.488	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.483	2

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