MAP2K2 N126D [cytosol]

Stable Identifier
R-HSA-9652079
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
MEK2, Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.1.-) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2), Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2
MAP2K2 N126D [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
24265153 The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

Taylor-Weiner, A, Gutzmer, R, Rosenberg, M, Treacy, DJ, Goldinger, SM, Gogas, HJ, Dermatologic Cooperative Oncology Group of Germany (DeCOG), -, Van Allen, EM, Garraway, LA, Farlow, D, Trefzer, U, Egberts, F, Place, CS, McKenna, A, Gabriel, SB, Schadendorf, D, Hodis, E, Carter, SL, Kryukov, GV, Wagle, N, Whittaker, S, Johannessen, CM, Hassel, JC, Weide, B, Berking, C, Loquai, C, Zimmer, L, Getz, G, Hillen, U, Ugurel, S, Goetz, EM, Cibulskis, K, Sucker, A

Cancer Discov 2014
External Reference Information
External Reference
Gene Names
MAP2K2, MEK2, MKK2, PRKMK2
Chain
chain:1-400
Reference Transcript
Other Identifiers
1131_at
11716318_x_at
202424_PM_at
202424_at
213490_PM_s_at
213490_s_at
3023305
3023308
3023309
3023310
3846639
3846640
3846643
3846645
3846646
3846650
3846652
3846653
3846654
3846659
3846660
3846663
3846664
3846665
3846666
5605
8032761
GE57609
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005777
GO:0005778
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005911
GO:0005925
GO:0006351
GO:0006355
GO:0006468
GO:0007507
GO:0009898
GO:0010628
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030165
GO:0030878
GO:0031410
GO:0032872
GO:0036211
GO:0036289
GO:0043226
GO:0043410
GO:0043539
GO:0045893
GO:0046872
GO:0048009
GO:0048471
GO:0048538
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0070371
GO:0071902
GO:0090170
GO:0097110
GO:0098772
GO:0106310
GO:0140096
GO:2000147
GO:2000641
Hs.72241.1.S1_3p_a_at
ILMN_1657968
L11285_at
PH_hs_0029886
TC19001058.hg
g13489053_3p_at
g13489053_3p_x_at
Participates
Other forms of this molecule
Modified Residues
Name
L-asparagine 126 replaced with L-aspartic acid
Coordinate
126
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
A protein modification that effectively removes or replaces an L-asparagine.
Disease
Name Identifier Synonyms
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
COSMIC
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (21)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P10398 ARAF  4 0.878 9
 UniProt:P15056 BRAF  20 0.848 11
 UniProt:P04049 RAF1  20 0.804 6
 UniProt:Q8IVT5 KSR1  5 0.738 9
 UniProt:Q04917 YWHAH  1 0.643 4
 UniProt:P27348 YWHAQ  1 0.643 4
 UniProt:P31946 YWHAB  1 0.643 4
 UniProt:Q96II5 Q96II5      0.601 4
 UniProt:P61981 YWHAG  1 0.569 3
 UniProt:P61978-2 HNRNPK      0.556 3
 UniProt:O95273 CCDB1      0.556 3
 UniProt:P00540 MOS      0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:Q92905 COPS5  2 0.553 2
 UniProt:Q12959 DLG1  4 0.543 10
 UniProt:P68366 TUBA4A  9 0.527 3
 UniProt:P04439 HLA-A  9 0.527 2
 UniProt:Q6VAB6 KSR2  1 0.527 7
 UniProt:P11142 HSPA8  10 0.527 3
 UniProt:Q61097  5 0.508 2
 UniProt:P06929 VE6      0.488 2
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