p-T185,Y187 MAPK1 S142L [cytosol]

Stable Identifier
R-HSA-9652808
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
ERK2, Mitogen-activated protein kinase 1 (EC 2.7.1.-) (Extracellular signal- regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1), Mitogen-activated protein kinase 1 , Extracellular signal-regulated kinase 2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1, ERK-2
p-T185,Y187 MAPK1 S142L [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
27760319 Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

Pantel, S, Garraway, LA, Johannessen, CM, Cacchiarelli, D, Getz, G, Persky, NS, Brenan, L, Piccioni, F, Cohen, O, Root, DE, Goetz, EM, Zhu, C, Andreev, A, Burgin, AB, Mikkelsen, TS, Bagul, M, Kamburov, A

Cell Rep 2016
28481359 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ladanyi, M, Wills, J, Rema, AB, Syed, A, Srinivasan, P, Raj, N, Mullaney, KA, Vakiani, E, Nafa, K, Shah, RH, Kundra, R, Razumova, A, Ochoa, A, Phillips, S, Jordan, EJ, Morris, LGT, Berger, MF, Thomas, SB, Camacho, N, Hellmann, MD, Hechtman, JF, Feldman, DR, Coleman, J, Mohanty, AS, Ptashkin, RN, Syed, MH, Wang, J, Saltz, LB, Reales, DN, Cheng, DT, Arcila, ME, Eubank, M, Benayed, R, Chakravarty, D, Harding, JJ, Prasad, M, Bochner, B, Durany, R, Zehir, A, Gross, BE, Zhang, H, Janjigian, YY, Iyer, G, DeLair, DF, Klimstra, DS, Robson, ME, Chen, HW, Cercek, A, Kelly, CM, Varghese, AM, Taylor, BS, Yaeger, R, Schultz, N, Hyman, DM, Won, HH, Solit, DB, Razavi, P, Chang, MT, Riely, GJ, Abeshouse, AA, Kiecka, IJ, Jayakumaran, G, Chandramohan, R, Casanova, J, Bacares, R, Abida, W, Gao, J, Soumerai, TE, Lowery, MA, Stewart, L, Ross, DS, Shukla, N, Yao, J, Al-Ahmadie, H, Penson, AV, Kim, HR, Baldi, T, Mandelker, DL, Gardos, SM, Galle, J, Heins, ZJ, Barron, DA, Shoushtari, AN, Scher, HI, Sadowska, J, Jonsson, P, Hakimi, AA, Omuro, AM, Son, JB, Sabbatini, PJ, Borsu, L, Dogan, S, Devlin, SM, Cambria, R, Hameed, M, Baselga, J, Liu, ZY, Schram, AM, Gounder, MM, Middha, S

Nat. Med. 2017
External Reference Information
External Reference
Gene Names
MAPK1, ERK2, PRKM1, PRKM2
Chain
initiator methionine:, chain:2-360
Other Identifiers
11715841_at
11715842_a_at
11715843_at
11738871_a_at
11738872_x_at
11751223_a_at
11751224_x_at
11753379_a_at
1552263_PM_at
1552263_at
1552264_PM_a_at
1552264_a_at
16932831
208351_PM_s_at
208351_s_at
212271_PM_at
212271_at
224621_PM_at
224621_at
3954239
3954240
3954241
3954242
3954243
3954244
3954245
3954246
3954248
3954249
3954252
3954256
3954257
3954261
3954262
3954264
3954266
3954273
3954274
45715_at
55528_at
5594
8074791
976_s_at
A_23_P257895
A_24_P237265
GE476071
GE534117
GE56878
GE86009
GO:0000165
GO:0000166
GO:0001784
GO:0002376
GO:0003677
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0004708
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0006915
GO:0006935
GO:0006974
GO:0007010
GO:0007049
GO:0007165
GO:0007166
GO:0007268
GO:0007507
GO:0007611
GO:0008286
GO:0008353
GO:0009887
GO:0010759
GO:0010800
GO:0012501
GO:0014032
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019858
GO:0019902
GO:0023052
GO:0030154
GO:0030278
GO:0030521
GO:0030641
GO:0030878
GO:0031143
GO:0031410
GO:0031647
GO:0031663
GO:0032200
GO:0032212
GO:0032496
GO:0032872
GO:0033598
GO:0034198
GO:0034614
GO:0035094
GO:0035556
GO:0035578
GO:0036211
GO:0038127
GO:0042473
GO:0042802
GO:0043226
GO:0043330
GO:0043401
GO:0045202
GO:0045596
GO:0048009
GO:0048538
GO:0048856
GO:0048870
GO:0050847
GO:0050852
GO:0050853
GO:0050877
GO:0051403
GO:0051493
GO:0051973
GO:0055086
GO:0060020
GO:0060291
GO:0060324
GO:0060425
GO:0060440
GO:0060716
GO:0061308
GO:0070161
GO:0070371
GO:0070849
GO:0071276
GO:0071356
GO:0072584
GO:0072686
GO:0090170
GO:0106310
GO:0120041
GO:0140096
GO:1904355
GO:1904813
GO:2000641
HMNXSV003015938
HMNXSV003030947
Hs.324473.2.S1_3p_at
Hs.66151.0.S1_3p_at
Hs2.324473.2.S1_3p_at
ILMN_1706677
ILMN_1767320
ILMN_2235283
PH_hs_0016141
PH_hs_0039033
TC22000547.hg
Z11695_at
g4506086_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
L-serine 142 replaced with L-leucine
Coordinate
142
PsiMod
A protein modification that effectively removes or replaces an L-serine.
A protein modification that effectively converts a source amino acid residue to an L-leucine.
Name
O4'-phospho-L-tyrosine at 185
Coordinate
185
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 187
Coordinate
187
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
ZINC - Metabolites
COSMIC
IntEnz
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (55)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q15418 RPS6KA1  7 0.86 10
 UniProt:Q15349 RPS6KA2  7 0.845 10
 UniProt:P51812 RPS6KA3  7 0.837 10
 UniProt:Q13115 DUSP4  1 0.806 6
 UniProt:P35236 PTPN7  2 0.767 6
 UniProt:Q9BUB5 MKNK1  1 0.765 10
 UniProt:Q16828 DUSP6  2 0.758 5
 UniProt:P27361 MAPK3  6 0.706 6
 UniProt:P0A2M9 SPVC      0.683 3
 UniProt:Q15121 PEA15  1 0.675 4
 UniProt:Q8VSP9 OSPF      0.672 5
 UniProt:Q9BRK4 LZTS2      0.666 4
 UniProt:Q99956 DUSP9  1 0.659 4
 UniProt:Q16539-3 MAPK14      0.628 5
 UniProt:P02687 MBP      0.623 2
 UniProt:P29353-2 SHC1  6 0.618 4
 UniProt:P35813 PPM1A  2 0.611 19
 UniProt:P28482 MAPK1  18 0.609 3
 UniProt:Q02750 MAP2K1  20 0.609 2
 UniProt:Q15256 PTPRR      0.583 3
 UniProt:Q9Y296 TRAPPC4  2 0.581 3
 UniProt:Q12913 PTPRJ  2 0.578 7
 UniProt:Q05922  1 0.558 2
 UniProt:O76064 RNF8  1 0.556 3
 UniProt:Q99750 MDFI      0.556 3
 UniProt:Q15256-5 PTPRR      0.556 3
 UniProt:P61764 STXBP1  2 0.556 3
 UniProt:P25786 PSMA1  2 0.556 3
 UniProt:Q08117-2 TLE5      0.556 3
 IntAct:EBI-16436244 CCSB ORF ID      0.556 3
 UniProt:P62487 POLR2G  1 0.556 3
 UniProt:Q6NYC8 PPR18      0.556 3
 UniProt:P35548 MSX2  1 0.556 3
 UniProt:A0A384NQ31 A0A384NQ31      0.556 3
 UniProt:A2A3K4 PTPC1      0.556 3
 UniProt:P15882 CHN1  1 0.556 3
 UniProt:Q9UPG8 PLAL2      0.556 3
 UniProt:B2RXF5 ZBT42      0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:P28562 DUSP1  1 0.544 3
 UniProt:Q7L5N1 COPS6  2 0.544 2
 UniProt:Q16690 DUSP5  1 0.543 3
 UniProt:P14921 ETS1  2 0.528 3
 UniProt:P49366 DHPS  1 0.527 8
 UniProt:Q15256-3 PTPRR      0.527 2
 UniProt:Q9U1H0 CIC      0.527 2
 UniProt:P50548 ERF  3 0.527 4
 UniProt:P54829 PTPN5  1 0.527 2
 UniProt:P06239 LCK  4 0.524 2
 UniProt:P53004 BLVRA  1 0.499 2
 UniProt:P10415 BCL2  1 0.488 2
 UniProt:Q15025 TNIP1  1 0.488 2
 UniProt:P32121 ARRB2  2 0.483 3
 UniProt:P13569 CFTR  17 0.483 6
 UniProt:P46531 NOTCH1  20 0.462 2
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