Reactome | KRAS L19F [plasma membrane]

KRAS L19F [plasma membrane]

Stable Identifier

R-HSA-9653097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - RAS GTPase cycle mutants (Homo sapiens)
        
        Signaling by RAS GAP mutants (Homo sapiens)
        
        RAS GAP mutants aren't stimulated by GAPs (Homo sapiens)
        
        RAS GAP mutants:GTP [plasma membrane] (Homo sapiens)
        
        RAS GAP mutants [plasma membrane] (Homo sapiens)
        
        KRAS L19F [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
20147967	Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine Smith, G, Bounds, R, Wolf, H, Steele, RJ, Carey, FA, Wolf, CR	Br. J. Cancer	2010
17150185	Characterization of a novel oncogenic K-ras mutation in colon cancer Akagi, K, Uchibori, R, Yamaguchi, K, Kurosawa, K, Tanaka, Y, Kozu, T	Biochem. Biophys. Res. Commun.	2007

External Reference Information

External Reference

UniProt:P01116 KRAS

Gene Names

KRAS, KRAS2, RASK2

Chain

chain:1-186, initiator methionine:1, chain:2-186, propeptide:187-189

Reference Genes

BioGPS Gene:3845 KRAS

COSMIC (genes):KRAS KRAS

CTD Gene:3845 KRAS

dbSNP Gene:3845 KRAS

ENSEMBL:ENSG00000133703 KRAS

HGNC:6407 KRAS

KEGG:hsa:3845 KRAS

Monarch:3845 KRAS

NCBI Gene:3845 KRAS

OMIM:190070 KRAS

UCSC:P01116 KRAS

Reference Transcript

Participates

as a member of

RAS GAP mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule

S-Farn-Me-PalmS KRAS [plasma membrane]

p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]

KRAS A146T [plasma membrane]

KRAS K147E [plasma membrane]

KRAS K147T [plasma membrane]

KRAS V14G [plasma membrane]

KRAS K147N [plasma membrane]

KRAS A146V [plasma membrane]

KRAS A146S [plasma membrane]

KRAS A146P [plasma membrane]

KRAS P34R [plasma membrane]

KRAS P34L [plasma membrane]

KRAS G12A [plasma membrane]

KRAS G12R [plasma membrane]

KRAS G13V [plasma membrane]

KRAS G13S [plasma membrane]

KRAS G13C [plasma membrane]

KRAS G13R [plasma membrane]

KRAS G13A [plasma membrane]

KRAS K5N [plasma membrane]

KRAS G12S [plasma membrane]

KRAS Q61L [plasma membrane]

KRAS Q61K [plasma membrane]

KRAS Q61R [plasma membrane]

KRAS F156L [plasma membrane]

KRAS G12C [plasma membrane]

proKRAS [cytosol]

S-Farn-proKRAS [endoplasmic reticulum membrane]

S-Farn-KRAS [endoplasmic reticulum membrane]

S-Farn-Me KRAS [endoplasmic reticulum membrane]

KRAS [plasma membrane]

KRAS A59T [plasma membrane]

KRAS E63K [plasma membrane]

KRAS G60D [plasma membrane]

KRAS G60V [plasma membrane]

KRAS Q22K [plasma membrane]

KRAS D33E [plasma membrane]

KRAS G60R [plasma membrane]

KRAS T58I [plasma membrane]

KRAS G13D [plasma membrane]

KRAS D153V [plasma membrane]

KRAS G12V [plasma membrane]

KRAS V14I [plasma membrane]

KRAS Q61H [plasma membrane]

KRAS Q22R [plasma membrane]

KRAS K117N [plasma membrane]

KRAS Q22E [plasma membrane]

KRAS G12D [plasma membrane]

Modified Residues

Name

L-leucine 19 replaced with L-phenylalanine

Coordinate

PsiMod

L-phenylalanine residue [MOD:00023]

A protein modification that effectively converts a source amino acid residue to L-phenylalanine.

L-leucine removal [MOD:01641]

A protein modification that effectively removes or replaces an L-leucine.

Disease

Name	Identifier	Synonyms
urinary system cancer	DOID:3996
colorectal cancer	DOID:9256
hematologic cancer	DOID:2531	hematopoietic cancer, hematopoietic tumors, Hematologic neoplasm (disorder), Hematologic malignancy, hematopoietic neoplasm (morphologic abnormality), Hematologic malignancy (disorder), Hematological tumors, blood cancer, hematopoietic and lymphoid system tumor, malignant hematopoietic neoplasm (morphologic abnormality)

Cross References

RefSeq

NP_203524.1, NP_004976.2, XP_011518955.1, NP_001356716.1, NP_001356715.1, XP_006719132.1

Guide to Pharmacology - Targets

2824

OpenTargets

ENSG00000133703

ENSEMBL

ENSP00000509238, ENST00000311936, ENSP00000256078, ENST00000685328, ENST00000688940, ENSG00000133703, ENST00000256078, ENSP00000308495, ENSP00000508921

Mondo

0002334

ZINC - Substances

RASK_HUMAN

ZINC target

P01116

PRO

P01116

PDB

6GJ6, 8STM, 6F76, 8R7W, 8T75, 6V6F, 4TQ9, 8EDY, 8B00, 1N4R, 6TAN, 5VBM, 4M21, 6GOG, 6USX, 4PZZ, 8TBK, 4M1T, 6P8Y, 6QUX, 8QUG, 8G9Q, 7EYX, 7T47, 6YR8, 2MSD, 8X6R, 5V71, 6ASE, 7ROV, 9BI1, 5WHE, 6FA1, 7KYZ, 8TXK, 7MDP, 7EWA, 7STF, 8EZG, 6T5B, 8FMI, 7RP3, 8WTE, 6W4F, 8AZV, 8B6I, 4DSN, 6O46, 6OIM, 8AFD, 8STN, 8R7X, 8AQ7, 8PI0, 7RT3, 6GQY, 5VQ8, 8TBH, 1N4Q, 4TQA, 6TAM, 6PTW, 9BG1, 5VP7, 8VR9, 8DVG, 8G4F, 7T1F, 6UT0, 5OCT, 6MBU, 5VQ6, 5O2T, 7OK4, 7RSE, 8DGT, 5KYK, 6XGV, 6B0Y, 6PQ3, 6XHA, 6VJJ, 8K4V, 6WS2, 8TY2, 8AZY, 7LC1, 7EWB, 6EPP, 8FMJ, 5TB5, 7RP4, 7O70, 8EIE, 8BE3, 6O4Z, 6GJ5, 7Q9U, 8UN5, 7KMR, 4OBE, 6OB2, 8ONV, 5VQ1, 7A1X, 6GQX, 7ACH, 8T74, 6GOF, 4LYF, 4LRW, 8TBF, 4M22, 8JGD, 6P8X, 7RSC, 6ARK, 8DGS, 9KPM, 8PIY, 8QU8, 7RT5, 4EPW, 2MSC, 7R0Q, 8EBZ, 6XGU, 8WUL, 6MS9, 9BHQ, 8BE4, 8EPW, 8TXH, 6BOF, 6CCX, 8T73, 8AZZ, 8CX5, 8TXG, 6W4E, 5WPM, 4DSO, 6FA4, 7TLK, 6USZ, 6O36, 5V9L, 4Q03, 6GJ8, 1KZO, 8AQ5, 9E5F, 4LDJ, 7ACA, 6T5V, 7A1W, 5VQ0, 8UN4, 7C40, 4L8G, 4M1Y, 8QVU, 8EER, 8TBL, 6QUU, 7RT4, 5VPZ, 4M1W, 6ASA, 6JTP, 6V65, 8DNJ, 6JTO, 6XHB, 7RPZ, 7VVB, 6P8Z, 9BI2, 8K4T, 8ECR, 6EPL, 8RRO, 8UN3, 1N4P, 8YJ2, 8AZR, 6EPO, 7F0W, 7A47, 6FA3, 6MQG, 5WHD, 6O51, 9BFY, 8AFB, 6PTS, 8JHL, 5V6V, 7OO7, 7KFZ, 7LZ5, 5V9O, 6T5U, 5OCO, 8VGQ, 8TBN, 9BFW, 4LYH, 6E6G, 8QW6, 8TBM, 6QUW, 7A1Y, 5O2S, 5VQ2, 4EPX, 5OCG, 5VPI, 6ZL5, 8VJZ, 4EPR, 6JTN, 7EW9, 9BHO, 4LV6, 8I5C, 6VC8, 6O4Y, 5US4, 4Q01, 8DNK, 8TXE, 6WS4, 8FMK, 8YIV, 9AX6, 4QL3, 6OB3, 7ACQ, 6ZLI, 5UQW, 6V5L, 6GJ7, 7RP2, 6E6F, 5WLB, 4LYJ, 7YV1, 8T71, 8I5E, 8TVK, 6GOE, 8T4V, 8RNI, 8QW7, 5W22, 5VPY, 8G4H, 7RT1, 7C41, 4LPK, 9KPN, 1D8D, 8B69, 4EPY, 6N2K, 8CPR, 6YXW, 6M9W, 5WHA, 8VRA, 6B0V, 5UFE, 8JJS, 7TLE, 8I5D, 6FA2, 7YCE, 7NY8, 8TY9, 9E9I, 8UDR, 8VRB, 8AZX, 8V3A, 1KZP, 6EPN, 5F2E, 7W5R, 6WGN, 4NMM, 8T72, 8AFC, 8F0M, 9E5D, 7ACF, 6H47, 5YY1, 7U8H, 6GQT, 8G9P, 4M1S, 5XCO, 8TBJ, 7SCW, 6MBT, 7R0M, 3GFT, 7LGI, 8S8C, 4EPT, 7TLG, 6PGP, 5TAR, 6CCH, 5MLA, 2MSE, 6MQN, 4Q02, 8TXJ, 6MNX, 8G42, 7LC2, 7YUZ, 8BE5, 5UK9, 4PZY, 7MQU, 9C15, 9BFZ, 1N4S, 5UFQ, 6MTA, 5YXZ, 6BP1, 5V9U, 1D8E, 6H46, 6P0Z, 6P8W, 6QUV, 6GOD, 6CC9, 7SCX, 7RT2, 8B78, 4M1O, 6GQW, 6GOM, 7OK3, 6MBQ, 8K50, 9E9H, 4EPV, 6N2J, 7R0N, 5MLB, 6PGO, 4WA7, 9BHP, 8TY8, 4LUC, 8BLR, 6O53, 5WHB, 6CU6, 8DNI, 5USJ, 8V39, 5V6S, 8G47, 7YCC, 6EPM

COSMIC

COSV55502103, COSV55521217

GeneCards

KRAS

HPA

ENSG00000133703-KRAS

Pharos - Targets

P01116

Orphanet

KRAS

HMDB Protein

HMDBP08526

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.695	6
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.68	5
UniProt:Q99755 PIP5K1A	1	PIP5K1A [cytosol] (R-HSA-1806260)	0.661	9
UniProt:Q96II5 Q96II5			0.556	3
UniProt:P50749 RASF2			0.544	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.519	2
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.519	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.483	2
UniProt:P28288 ABCD3	2	ABCD3 [cytosol] (R-HSA-1456459) ABCD3 [peroxisomal membrane] (R-HSA-1456468)	0.483	2
UniProt:P01111 NRAS	20	S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) proNRAS [cytosol] (R-HSA-9647758) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS [plasma membrane] (R-HSA-62725) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12V [plasma membrane] (R-HSA-9649666)	0.483	2
UniProt:Q7KZI7 MARK2			0.483	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.483	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2

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