USP17L2 deubiquitinates RCE1

Stable Identifier
R-HSA-9653514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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USP17L2 deubiquitinates RCE1
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USP17L2, also known as USP17, deubiquitinates RCE1 (RAS-converting enzyme 1), inactivating it. Loss of RCE1 activity after USP17L2-mediated deubiquitination interferes with RAS localization and function and prevents downstream signaling through the RAF MAP kinase cascade (Burrows et al, 2009).
Literature References
PubMed ID Title Journal Year
19188362 USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity

McFarlane, C, Scott, CJ, De la Vega, M, Johnston, JA, McGrattan, MJ, Kelvin, AA, Burden, RE, Govender, U, Dib, K, Quinn, DJ, Burrows, JF, Gadina, M

J. Biol. Chem. 2009
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Catalyst Activity

cysteine-type deubiquitinase activity of USP17L2 [cytosol]

Physical Entity
USP17L2 [cytosol] (Homo sapiens)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Orthologous Events
USP17L2 deubiquitinates RCE1 (Bos taurus)
USP17L2 deubiquitinates RCE1 (Caenorhabditis elegans)
USP17L2 deubiquitinates RCE1 (Canis familiaris)
USP17L2 deubiquitinates RCE1 (Drosophila melanogaster)
USP17L2 deubiquitinates RCE1 (Mus musculus)
USP17L2 deubiquitinates RCE1 (Rattus norvegicus)
USP17L2 deubiquitinates RCE1 (Saccharomyces cerevisiae)
USP17L2 deubiquitinates RCE1 (Schizosaccharomyces pombe)
USP17L2 deubiquitinates RCE1 (Sus scrofa)
Authored
Rothfels, K  (2019-10-25)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2019-07-11)
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