pS181-S-Farn-Me KRAS4B binds BCL2L1

Stable Identifier
R-HSA-9653595
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the mitochondrial outer membrane, phosphorylated KRAS4B binds BCL2L1 (also known as BCL-XL) to promote apoptosis (Bivona et al, 2006; reviewed in Ahearn et al, 2018).
Literature References
PubMed ID Title Journal Year
29311131 Posttranslational Modifications of RAS Proteins

Philips, MR, Zhou, M, Ahearn, I

Cold Spring Harb Perspect Med 2018
16483930 PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis

Philips, MR, Bivona, TG, Thompson, CB, Ahearn, IM, Mor, A, PĂ©rez De Castro, I, Saba, SG, Yim, D, Cox, AD, Bodemann, BO, Wiener, HH, Soskis, MJ, Fein, A, Miura, J, Quatela, SE, Li, C, Wright, L

Mol. Cell 2006
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!