Reactome | CBX1 [nucleoplasm]

CBX1 [nucleoplasm]

Stable Identifier

R-HSA-9653629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromobox protein homolog 1, CBX1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P83916 CBX1

Gene Names

CBX1, CBX

Chain

chain:1-185

Reference Genes

BioGPS Gene:10951 CBX1

COSMIC (genes):CBX1 CBX1

CTD Gene:10951 CBX1

dbSNP Gene:10951 CBX1

ENSEMBL:ENSG00000108468 CBX1

ENSEMBL_homo_sapiens_GENE:ENSG00000108468.15 CBX1

HGNC:1551 CBX1

KEGG Gene (Homo sapiens):10951 CBX1

Monarch:10951 CBX1

NCBI Gene:10951 CBX1

OMIM:604511 CBX1

Reference Transcript

Other Identifiers

10951

11715546_s_at

16846181

201518_PM_at

201518_at

37304_at

3761126

3761128

3761129

3761130

3761132

3761133

3761134

3761135

3761138

3761139

3761140

3761141

4010449

4010450

4010451

8016402

A_23_P107507

A_24_P296568

GE59106

GO:0000122

GO:0000775

GO:0000781

GO:0000785

GO:0000792

GO:0001939

GO:0001940

GO:0003677

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0005819

GO:0005856

GO:0006325

GO:0006351

GO:0006355

GO:0006974

GO:0010369

GO:0016604

GO:0019899

GO:0035064

GO:0042393

GO:0042802

GO:0043226

GO:0043231

GO:0045892

GO:0060090

GO:0090734

GO:1990226

HMNXSV003030618

ILMN_1770244

PH_hs_0027694

TC17001635.hg

U35451_at

g5803075_3p_at

Participates

as an input of

Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)

as an output of

Activation of Latent HCMV Genome (Homo sapiens)

as a component of

Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_006798.1, NP_001120700.1

OpenTargets

ENSG00000108468

GeneCards

P83916

HPA

ENSG00000108468-CBX1

Ensembl

ENST00000225603, ENSP00000225603, ENSP00000377060, ENSG00000108468, ENST00000393408

ZINC target

P83916

PRO

P83916

Pharos - Targets

P83916

PDB

3F2U, 3Q6S, 5T1G, 6D08, 6D07, 2FMM

Interactors (65)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.834	13
UniProt:Q6IQ32 ADNP2			0.823	6
UniProt:Q96JM3 CHAP1			0.788	5
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.788	6
UniProt:Q7Z3K3 POGZ			0.788	5
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.788	6
UniProt:Q13263 TRIM28	3	SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600) TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867)	0.788	8
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.788	7
UniProt:Q9H2P0 ADNP			0.773	5
UniProt:Q8ND82 Z280C			0.742	5
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.742	6
UniProt:Q9BWN1 PRR14			0.725	4
UniProt:Q13112 CAF1B			0.725	4
UniProt:Q13111 CAF1A			0.725	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.725	5
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.666	4
UniProt:Q6N043 Z280D			0.643	3
UniProt:O95785 WIZ			0.643	3
UniProt:Q5TGY3 AHDC1			0.643	3
UniProt:Q9H081 MIS12	1	MIS12 [cytosol] (R-HSA-375313)	0.643	3
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.643	3
UniProt:Q9H410 DSN1	3	DSN1 [cytosol] (R-HSA-375308) DSN1 [azurophil granule lumen] (R-HSA-6799218) DSN1 [extracellular region] (R-HSA-6806228)	0.643	3
UniProt:Q96IY1 NSL1	1	NSL1 [cytosol] (R-HSA-375309)	0.643	3
UniProt:Q6P1K2 PMF1	1	PMF1 [cytosol] (R-HSA-375320)	0.643	3
UniProt:Q9H582 ZN644			0.643	3
UniProt:Q5T3J3 LRIF1			0.643	4
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.643	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	4
UniProt:Q7Z589 EMSY			0.618	3
UniProt:Q9D752	1	Mad2l2 [nucleoplasm] (R-MMU-59092)	0.564	2
UniProt:P50570-2 DNM2			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:P23497-2 SP100			0.556	3
IntAct:EBI-22329726 CCSB ORF ID			0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q92673 SORL1	2	SORL1 [endosome membrane] (R-HSA-8871475) SORL1 [Golgi membrane] (R-HSA-8871510)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:Q5FBB7 SGO1	1	SGOL1 [cytosol] (R-HSA-376227)	0.544	2
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.527	2
UniProt:Q9P0T4 ZN581			0.527	2
UniProt:Q9H5I1 SUV39H2	1	SUV39H2 [nucleoplasm] (R-HSA-1183231)	0.527	2
UniProt:Q5VZL5 ZMYM4			0.527	2
UniProt:P61244 MAX	1	MAX [nucleoplasm] (R-HSA-3006627)	0.527	2
UniProt:P12956 XRCC6	5	XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [nucleoplasm] (R-HSA-58272)	0.527	2
UniProt:Q86XI8 ZSWM9			0.527	2
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.527	2
UniProt:Q14202 ZMYM3			0.527	2
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.527	2
UniProt:O60281 ZN292			0.527	2
UniProt:Q9Y6X3 MAU2	1	MAU2 [nucleoplasm] (R-HSA-1629801)	0.527	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.527	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	3
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.527	2
UniProt:Q8N9R8 SCAI	1	SCAI [nucleoplasm] (R-HSA-5666012)	0.527	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.527	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.527	3
UniProt:P10588 NR2F6	1	NR2F6 [nucleoplasm] (R-HSA-376279)	0.524	2
UniProt:Q9Y232 CDYL			0.491	2

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