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ATF5 [nucleoplasm]
Stable Identifier
R-HSA-9653719
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cyclic AMP-dependent transcription factor ATF-5, ATF5_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P53567 CEBPG
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Mitochondrial unfolded protein response (UPRmt) (Homo sapiens)
ATF5 activates expression of DEFA5 (Homo sapiens)
ATF5 [nucleoplasm] (Homo sapiens)
ATF5 activates expression of LONP1 (Homo sapiens)
ATF5 [nucleoplasm] (Homo sapiens)
ATF5 and HSF1 trimer bind the HSPA9 gene (Homo sapiens)
ATF5 [nucleoplasm] (Homo sapiens)
ATF5 and HSF1 trimer bind the bidirectional promoter of the HSPD1 gene and HSPE1 gene (Homo sapiens)
ATF5 [nucleoplasm] (Homo sapiens)
ATF5 translocates from the cytosol to the nucleoplasm (Homo sapiens)
ATF5 [nucleoplasm] (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Translation of ATF5 (Homo sapiens)
ATF5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2D1 ATF5
Gene Names
ATF5, ATFX
Chain
chain:1-282
Reference Genes
BioGPS Gene:22809 ATF5
COSMIC (genes):ATF5 ATF5
CTD Gene:22809 ATF5
dbSNP Gene:22809 ATF5
ENSEMBL:ENSG00000169136 ATF5
HGNC:790 ATF5
KEGG:hsa:22809 ATF5
Monarch:22809 ATF5
NCBI Gene:22809 ATF5
OMIM:606398 ATF5
UCSC:Q9Y2D1 ATF5
Reference Transcript
RefSeq:XM_011526629.2 ATF5
RefSeq:NM_001193646.1 ATF5
RefSeq:NM_012068.5 ATF5
RefSeq:NM_001290746.1 ATF5
Other Identifiers
11717800_a_at
11717801_a_at
11717802_s_at
11754592_x_at
16864393
17126000
204998_PM_s_at
204998_s_at
204999_PM_s_at
204999_s_at
22809
230938_3p_x_at
230938_PM_x_at
230938_x_at
3839104
3839105
3839106
3839107
3839108
3839109
3839110
3839111
3839112
3839113
3839114
3839115
3839116
3839117
3839118
39158_at
62994_at
8030557
GE53591
GO:0000785
GO:0000976
GO:0000977
GO:0000981
GO:0001228
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006355
GO:0006357
GO:0007623
GO:0008092
GO:0008285
GO:0009791
GO:0010468
GO:0015631
GO:0019900
GO:0021889
GO:0021891
GO:0021930
GO:0021988
GO:0030154
GO:0035264
GO:0042981
GO:0043066
GO:0043226
GO:0043565
GO:0045444
GO:0045892
GO:0045893
GO:0045944
GO:0046605
GO:0048856
GO:0090575
GO:0140110
GO:1902750
HMNXSV003000678
HMNXSV003034323
Hs.9754.3.A1_3p_a_at
ILMN_1669113
PH_hs_0001010
TC19000751.hg
TC19002201.hg
g12597624_3p_a_at
g13477389_3p_a_at
Participates
as an output of
Translation of ATF5 (Homo sapiens)
ATF5 translocates from the cytosol to the nucleoplasm (Homo sapiens)
as an input of
ATF5 and HSF1 trimer bind the bidirectional promoter of the HSPD1 gene and HSPE1 gene (Homo sapiens)
ATF5 and HSF1 trimer bind the HSPA9 gene (Homo sapiens)
as a component of
ATF5:HSF1 trimer:HSPD1 gene:HSPE1 gene [nucleoplasm] (Homo sapiens)
ATF5:HSF1 trimer:HSPA9 gene [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
ATF5 activates expression of DEFA5
(Homo sapiens)
ATF5 activates expression of LONP1
(Homo sapiens)
Other forms of this molecule
ATF5 [mitochondrial matrix]
ATF5 [cytosol]
Inferred To
Atf5 [nucleoplasm]
(Mus musculus)
Atf5 [nucleoplasm]
(Rattus norvegicus)
atf5a [nucleoplasm]
(Danio rerio)
crc [nucleoplasm]
(Drosophila melanogaster)
zip1 [nucleoplasm]
(Schizosaccharomyces pombe)
atf5 [nucleoplasm]
(Xenopus tropicalis)
MET4 [nucleoplasm]
(Saccharomyces cerevisiae)
ATF5 [nucleoplasm]
(Bos taurus)
ATF5 [nucleoplasm]
(Canis familiaris)
ATF5 [nucleoplasm]
(Sus scrofa)
atf-4 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENSP00000470633
,
ENSP00000396954
,
ENST00000595125
OpenTargets
ENSG00000169136
HPA
ENSG00000169136-ATF5
PRO
Q9Y2D1
Pharos - Targets
Q9Y2D1
HMDB Protein
HMDBP08115
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53567 CEBPG
1
CEBPG [nucleoplasm]
(R-HSA-9644320)
0.818
8
UniProt:P49715 CEBPA
1
CEBPA [nucleoplasm]
(R-HSA-381289)
0.623
2
IntAct:EBI-22318856 CCSB ORF ID
0.556
3
UniProt:Q14232 EIF2B1
1
EIF2B1 [cytosol]
(R-HSA-72517)
0.556
5
UniProt:Q13227 GPS2
1
GPS2 [nucleoplasm]
(R-HSA-351642)
0.556
3
UniProt:P02766 TTR
2
TTR [azurophil granule lumen]
(R-HSA-6799366)
TTR [extracellular region]
(R-HSA-976883)
0.556
3
UniProt:Q16204 CCDC6
0.556
3
UniProt:Q9NRI5 DISC1
0.543
8
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