Reactome | p-S621-RAF1 P261S [cytosol]

p-S621-RAF1 P261S [cytosol]

Stable Identifier

R-HSA-9656113

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf

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Literature References

PubMed ID	Title	Journal	Year
20052757	Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation Kobayashi, T, Aoki, Y, Niihori, T, Cavé, H, Verloes, A, Okamoto, N, Kawame, H, Fujiwara, I, Takada, F, Ohata, T, Sakazume, S, Ando, T, Nakagawa, N, Lapunzina, P, Meneses, AG, Gillessen-Kaesbach, G, Wieczorek, D, Kurosawa, K, Mizuno, S, Ohashi, H, David, A, Philip, N, Guliyeva, A, Narumi, Y, Kure, S, Tsuchiya, S, Matsubara, Y	Hum. Mutat.	2010
25589618	Genomic analysis of metastatic cutaneous squamous cell carcinoma Li, YY, Hanna, GJ, Laga, AC, Haddad, RI, Lorch, JH, Hammerman, PS	Clin. Cancer Res.	2015

External Reference Information

External Reference

UniProt:P04049 RAF1

Gene Names

RAF1, RAF

Chain

chain:1-648

Reference Genes

BioGPS Gene:5894 RAF1

COSMIC (genes):RAF1 RAF1

CTD Gene:5894 RAF1

dbSNP Gene:5894 RAF1

ENSEMBL:ENSG00000132155 RAF1

HGNC:9829 RAF1

KEGG:hsa:5894 RAF1

Monarch:5894 RAF1

NCBI Entrez Gene:5894 RAF1

OMIM:164760 RAF1

UCSC:P04049 RAF1

Reference Transcript

Other Identifiers

11716472_a_at

11748273_a_at

1557675_PM_at

1557675_at

16950848

1917_at

201244_PM_s_at

201244_s_at

2663243

2663245

2663246

2663247

2663248

2663249

2663250

2663251

2663252

2663253

2663254

2663255

2663256

2663257

2663258

2663259

2663260

2663261

2663262

2663263

2663264

2663265

2663269

2663270

2663271

2663272

2663273

2663274

2663275

2663277

2663278

2663279

2663280

2663281

2663282

2663283

2663284

2663288

2663289

2663290

2663291

2663292

38742_s_at

38743_f_at

42597_at

5894

67881_at

8085374

91863_at

A_23_P40952

GE59649

GE715347

GO:0000165

GO:0000166

GO:0001678

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005741

GO:0005794

GO:0005829

GO:0005886

GO:0006355

GO:0006468

GO:0006915

GO:0007010

GO:0007165

GO:0008270

GO:0008285

GO:0008286

GO:0008625

GO:0010856

GO:0014044

GO:0016020

GO:0016301

GO:0016740

GO:0019899

GO:0030154

GO:0030878

GO:0031143

GO:0031267

GO:0031333

GO:0033138

GO:0035019

GO:0035023

GO:0035773

GO:0035994

GO:0038133

GO:0042060

GO:0042552

GO:0042802

GO:0042981

GO:0043066

GO:0043410

GO:0044342

GO:0045104

GO:0045595

GO:0045944

GO:0046872

GO:0048009

GO:0048011

GO:0048538

GO:0048856

GO:0060324

GO:0060333

GO:0065003

GO:0071550

GO:0106310

GO:0140096

GO:1902042

HMNXSV003010706

HMNXSV003037375

Hs2.345050.1.A1_3p_at

ILMN_1813489

PH_hs_0010084

PH_hs_0039978

TC03001174.hg

X03484_at

g4506400_3p_a_at

Participates

as a member of

p-S621 RAF1 CR2 mutants [cytosol] (Homo sapiens)

Other forms of this molecule

p-S338,Y340,Y341-RAF1 [cytosol]

p-S338-RAF1 [cytosol]

p-S621-RAF1 S259F [cytosol]

p-S621-RAF1 S257L [cytosol]

p-S621-RAF1 P261L [cytosol]

p-S621-RAF1 N262K [cytosol]

p-S621-RAF1 P261A [cytosol]

p-S621-RAF1 S259T [cytosol]

p-S621-RAF1 P261T [cytosol]

p-S621-RAF1 P261R [cytosol]

p-S621-RAF1 S259P [cytosol]

p-S621-RAF1 T260I [cytosol]

p-S621-RAF1 T260R [cytosol]

p-S621-RAF1 V263A [cytosol]

p-S621-RAF1 R256S [cytosol]

p-S621-RAF1 T491I [cytosol]

p-S621-RAF1 D486N [cytosol]

p-S621-RAF1 S427G [cytosol]

p-S621-RAF1 L613V [cytosol]

p-S621-RAF1 G361A [cytosol]

p-S621-RAF1 G370R [cytosol]

p-S621-RAF1 D486G [cytosol]

p-S621-RAF1 T491R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]

p-S338,Y341,S494,S621-RAF1 T491I [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]

p-S338,Y341,S494,S621 RAF1 T491R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]

p-S338,Y341,T491,S494,S621 RAF1 [cytosol]

p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]

p-S621-RAF1 [cytosol]

p-Y-RAF1 [cytosol]

RAF1 [cytosol]

p-S259,S621-RAF1 [cytosol]

p-Y341,T491,S494,S621 RAF1 [plasma membrane]

p-S621-RAF1 [plasma membrane]

hyperphosphorylated RAF1 [plasma membrane]

p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]

p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]

Modified Residues

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

L-proline 261 replaced with L-serine

Coordinate

261

PsiMod

L-proline removal [MOD:01645]

A protein modification that effectively removes or replaces an L-proline.

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

Disease

Name	Identifier	Synonyms
melanoma	DOID:1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Noonan syndrome	DOID:3490	Turner's phenotype, karyotype normal (disorder)
hypertrophic cardiomyopathy	DOID:11984	familial hypertrophic cardiomyopathy, hypertrophic obstructive cardiomyopathy

Cross References

RefSeq

XP_054203390.1, NP_001341619.1, XP_047304606.1, NP_001341618.1, XP_005265412.1, XP_011532276.1, NP_002871.1, XP_054203389.1, XP_047304605.1, XP_054203391.1

ZINC - World Drugs

RAF1_HUMAN

Guide to Pharmacology - Targets

2184

ClinGen

CA257062

OpenTargets

ENSG00000132155

ENSEMBL

ENST00000691899, ENSP00000509968, ENSG00000132155, ENSP00000251849, ENSP00000401888, ENSP00000508763, ENST00000251849, ENST00000685653, ENST00000442415

Mondo

0018997, 0005045, 0005105

ZINC - FDA approved

RAF1_HUMAN

ZINC - Substances

RAF1_HUMAN

ZINC - Biogenic

RAF1_HUMAN

ZINC target

P04049

PRO

P04049

GlyGen

P04049

PDB

3O8I, 1C1Y, 4G3X, 9AYA, 1FAQ, 6PTW, 8ATR, 8EPW, 7JHP, 6NTC, 8S42, 1GUA, 7Z37, 6XGV, 9AXA, 6XHB, 8GAE, 6XHA, 8CHF, 3IQU, 8JOG, 3IQJ, 8A68, 3NKX, 4G0N, 8AV0, 1RFA, 8A6H, 6VJJ, 1FAR, 3OMV, 4IEA, 9AY7, 8GFT, 3KUD, 8ATS, 3KUC, 8T75, 8T74, 3CU8, 6PTS, 7Z38, 6XGU, 9AXC, 4FJ3, 6NTD, 8U1L, 3IQV, 4IHL, 8JOF, 6XI7, 8CPD, 8A6F

ZINC - Investigational

RAF1_HUMAN

COSMIC

COSV52578629

IntEnz

2.7.11.1

GeneCards

RAF1

HPA

ENSG00000132155-RAF1

Pharos - Targets

P04049

Orphanet

RAF1

ZINC - Predictions - Purchasable

RAF1_HUMAN

HMDB Protein

HMDBP01153

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.978	30
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.968	73
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.966	35
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.96	39
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.958	39
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.936	27
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.932	25
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.928	25
UniProt:P01111 NRAS	20	S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) proNRAS [cytosol] (R-HSA-9647758) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) NRAS [plasma membrane] (R-HSA-62725) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12V [plasma membrane] (R-HSA-9649666)	0.925	12
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.913	24
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.899	20
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.887	9
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.857	17
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.85	7
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.811	6
UniProt:P30086 PEBP1	1	PEBP1 [cytosol] (R-HSA-61487)	0.758	10
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)	0.744	15
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.738	7
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.695	6
UniProt:P01116-2 KRAS	8	pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane] (R-HSA-9653578) S-Farn-Me KRAS4B [cytosol] (R-HSA-9654510) pS181-S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9653482) S-Farn-Me KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649690) S-Farn KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649698) S-Farn proKRAS4B [endoplasmic reticulum membrane] (R-HSA-9649693) pro-KRAS4B [cytosol] (R-HSA-9649686) S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9647815)	0.676	3
UniProt:O95816 BAG2	1	BAG2 [cytosol] (R-HSA-5255445)	0.669	12
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.659	8
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	3
UniProt:Q13188 STK3	4	p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(1-491) [cytosol] (R-HSA-2028280) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.645	6
UniProt:P50990 CCT8	5	CCT8 [cytosol] (R-HSA-390449) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894)	0.643	7
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.643	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:O43852 CALU	3	CALU [extracellular region] (R-HSA-350739) p-CALU [endoplasmic reticulum lumen] (R-HSA-8956931) CALU [endoplasmic reticulum lumen] (R-HSA-350695)	0.643	4
UniProt:P62834 RAP1A	4	RAP1A [plasma membrane] (R-HSA-354118) RAP1A [endosome membrane] (R-HSA-190053) RAP1A [cytosol] (R-HSA-169884) RAP1A [specific granule membrane] (R-HSA-6806137)	0.623	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.623	3
UniProt:Q96S96 PEBP4			0.597	4
UniProt:Q6TCH7 PAQR3	1	PAQR3 [Golgi membrane] (R-HSA-5674103)	0.576	3
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [extracellular region] (R-HSA-351322)	0.576	5
UniProt:P32883 Kras	17	S-Farn-Me KRAS4B [plasma membrane] (R-MMU-9647815) S-Farn-Me-PalmS KRAS4A [plasma membrane] (R-MMU-9647915) pro-KRAS4A [cytosol] (R-MMU-9649683) proKRAS [cytosol] (R-MMU-9647762) S-Farn-proKRAS [endoplasmic reticulum membrane] (R-MMU-9647925) S-Farn proKRAS4B [endoplasmic reticulum membrane] (R-MMU-9649693) S-Farn KRAS4B [endoplasmic reticulum membrane] (R-MMU-9649698) S-Farn-KRAS [endoplasmic reticulum membrane] (R-MMU-9647790) S-Farn-Me KRAS4B [endoplasmic reticulum membrane] (R-MMU-9649690) S-Farn-Me KRAS [endoplasmic reticulum membrane] (R-MMU-9647801) phospho-pS181-S-Farn-Me KRAS4B [plasma membrane] (R-MMU-9653482) S-Farn-Me KRAS4B [cytosol] (R-MMU-9654510) S-Farn-Me PalmS KRAS4A [Golgi membrane] (R-MMU-9647903) S-Farn-Me KRAS4A [plasma membrane] (R-MMU-9647811) phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane] (R-MMU-9653578) Kras [plasma membrane] (R-MMU-1250483) phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-MMU-9674821)	0.573	2
UniProt:Q8IVT5 KSR1	5	p-S311,Y602 KSR1 [cytosol] (R-HSA-5672656) p-S311,Y602 KSR1 [plasma membrane] (R-HSA-5672659) p-S311 KSR1 [cytosol] (R-HSA-5672652) KSR1 [cytosol] (R-HSA-5672587) p-S311,S406 KSR1 [cytosol] (R-HSA-5672654)	0.564	5
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.564	8
UniProt:Q15773 MLF2			0.564	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.564	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.558	2
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:O39474 O39474			0.556	4
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.556	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.553	6
UniProt:Q13362 PPP2R5C	3	PPP2R5C [nucleoplasm] (R-HSA-3008946) p-S337-PPP2R5C [cytosol] (R-HSA-6811447) PPP2R5C [cytosol] (R-HSA-3008954)	0.544	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.544	2
UniProt:P78371 CCT2	3	CCT2 [cytosol] (R-HSA-390464) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220)	0.527	6
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.527	6
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.527	2
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	6
UniProt:P17066 HSPA6	5	HSPA6 [cytosol] (R-HSA-3371521) HSPA6 [nucleoplasm] (R-HSA-5252088) HSPA6 [ficolin-1-rich granule lumen] (R-HSA-6801512) HSPA6 [extracellular region] (R-HSA-6806500) HSPA6 [secretory granule lumen] (R-HSA-6801472)	0.527	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.527	9
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.527	3
UniProt:Q9H9S3 SEC61A2	2	SEC61A2 [endoplasmic reticulum membrane] (R-HSA-444585) SEC61A2 [phagocytic vesicle membrane] (R-HSA-1236771)	0.527	3
UniProt:Q96AG4 LRC59			0.527	2
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.527	2
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.527	6
UniProt:O14593 RFXK			0.527	3
UniProt:Q58FF7 H90B3			0.527	13
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	6
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	5
UniProt:Q8N163 CCAR2	2	DBC1 [nucleoplasm] (R-HSA-3371479) p-T454-DBC1 [nucleoplasm] (R-HSA-3371569)	0.527	9
UniProt:Q53GQ0 HSD17B12	1	HSD17B12 [endoplasmic reticulum membrane] (R-HSA-548766)	0.527	2
UniProt:O43324 EEF1E1	1	EEF1E1 [cytosol] (R-HSA-379693)	0.527	2
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.524	6
UniProt:P03495 NS1			0.508	2
UniProt:Q99933 BAG1	1	BAG1 [cytosol] (R-HSA-5255443)	0.508	2
UniProt:O15371 EIF3D	1	EIF3D [cytosol] (R-HSA-72548)	0.508	4
UniProt:P43246 MSH2	3	MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243) MSH2 R406* [nucleoplasm] (R-HSA-5575594)	0.508	2
UniProt:P28301	3	LOX(22-168) [extracellular region] (R-MMU-2022074) LOX(22-417) [extracellular region] (R-MMU-2022071) LOX [extracellular region] (R-MMU-2022085)	0.499	2
UniProt:Q9ESN9-2 MAPK8IP3			0.499	2
UniProt:P01120	2	RRAS2 [plasma membrane] (R-SCE-9715189) RRAS [plasma membrane] (R-SCE-396959)	0.499	2
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.488	5
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.483	7

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