ANO1 transports cytosolic Cl- to extracellular region

Stable Identifier
R-HSA-9659568
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Cytosolic Cl- is transported to extracellular region by ANO1
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Calcium-activated chloride channels (CaCCs) are ubiquitously expressed and implicated in physiological processes such as sensory transduction, fertilization, epithelial secretion, and smooth muscle contraction. The anoctamin family of transmembrane proteins (ANO, TMEM16) belong to CaCCs and have been shown to transport Cl- ions when activated by intracellular Ca2+ (Galietta 2009, Huang et al. 2012). ANO1 and 2 possess Ca2+ activated Cl- transport activity (Yang et al. 2008, Scudieri et al. 2012) while the remaining members also show some demonstrable activity (Tian et al. 2012).

Literature References
PubMed ID Title Journal Year
18724360 TMEM16A confers receptor-activated calcium-dependent chloride conductance

Yang, YD, Cho, H, Koo, JY, Tak, MH, Cho, Y, Shim, WS, Park, SP, Lee, J, Lee, B, Kim, BM, Raouf, R, Shin, YK, Oh, U

Nature 2008
22946059 Anoctamins are a family of Ca2+ activated Cl- channels

Tian, Y, Schreiber, R, Kunzelmann, K

J. Cell. Sci. 2012
21984732 The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels

Scudieri, P, Sondo, E, Ferrera, L, Galietta, LJ

Exp. Physiol. 2012
Participants
Participates
Catalyst Activity

intracellular calcium activated chloride channel activity of ANO1 [plasma membrane]

This event is regulated
Positively by
Regulator
Regulator
Summation

All CLCAs contain a consensus cleavage motif which is recognised by an internal zincin metalloprotease domain within the N terminus. Self-proteolysis within the secretory pathway yields N- and C-terminal fragments, a step critical for CLCA activation of calcium-activated chloride channels (CaCCs) mediated through the N-terminal fragment (Yurtsever et al. 2012).

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!