PolyUb-Misfolded PARK7 [lysosomal lumen]

Stable Identifier
R-HSA-9659997
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
PolyUb-L166P PARK7, PolyUb-Misfolded DJ-1
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q99497 PARK7
Gene Names
PARK7
Chain
initiator methionine:, chain:2-, propeptide:-189
Reference Genes
BioGPS Gene:11315 PARK7
COSMIC (genes):PARK7 PARK7
CTD Gene:11315 PARK7
dbSNP Gene:11315 PARK7
ENSEMBL:ENSG00000116288 PARK7
ENSEMBL_homo_sapiens_GENE:ENSG00000116288.13 PARK7
HGNC:16369 PARK7
KEGG Gene (Homo sapiens):11315 PARK7
Monarch:11315 PARK7
NCBI Gene:11315 PARK7
OMIM:602533 PARK7
Reference Transcript
Other Identifiers
11315
11742986_at
16658568
18670534
18670535
18670536
18670537
18670538
18670539
18670542
18670544
18670545
18670546
200006_PM_at
200006_at
2318737
2318738
2318739
2318740
2318741
2318743
2318744
2318746
2318747
2318751
2318754
2318755
2318756
2318757
2318871
38974_at
7893721
7893952
7894579
7895911
7896108
7896422
7896468
7897404
A_23_P74740
A_33_P3231981
D61380_at
GE81739
GO:0000785
GO:0001933
GO:0001963
GO:0002376
GO:0002866
GO:0003713
GO:0003723
GO:0003729
GO:0003824
GO:0005102
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005758
GO:0005759
GO:0005783
GO:0005829
GO:0005886
GO:0005912
GO:0006091
GO:0006281
GO:0006351
GO:0006355
GO:0006469
GO:0006508
GO:0006517
GO:0006520
GO:0006575
GO:0006790
GO:0006886
GO:0006913
GO:0006914
GO:0006954
GO:0006974
GO:0006979
GO:0007005
GO:0007265
GO:0007338
GO:0008233
GO:0008344
GO:0009438
GO:0010273
GO:0010628
GO:0010629
GO:0012501
GO:0016020
GO:0016209
GO:0016491
GO:0016532
GO:0016605
GO:0016684
GO:0016787
GO:0016829
GO:0019249
GO:0019826
GO:0019899
GO:0019900
GO:0019955
GO:0022414
GO:0023052
GO:0030073
GO:0030163
GO:0030424
GO:0031334
GO:0031397
GO:0032091
GO:0032148
GO:0032435
GO:0032757
GO:0033138
GO:0033234
GO:0033864
GO:0034599
GO:0034614
GO:0036211
GO:0036470
GO:0036471
GO:0036478
GO:0036524
GO:0036526
GO:0036527
GO:0036528
GO:0036529
GO:0036530
GO:0036531
GO:0042177
GO:0042542
GO:0042593
GO:0042743
GO:0042802
GO:0042803
GO:0043005
GO:0043226
GO:0043523
GO:0043524
GO:0044297
GO:0044388
GO:0044390
GO:0044877
GO:0045121
GO:0045202
GO:0045296
GO:0045340
GO:0045944
GO:0046295
GO:0046826
GO:0048471
GO:0050681
GO:0050727
GO:0050787
GO:0050821
GO:0051091
GO:0051444
GO:0051583
GO:0051881
GO:0051897
GO:0051899
GO:0051920
GO:0055086
GO:0060081
GO:0060765
GO:0061691
GO:0061727
GO:0065003
GO:0070062
GO:0070301
GO:0070994
GO:0097110
GO:0098754
GO:0098772
GO:0098793
GO:0098869
GO:0106044
GO:0106045
GO:0106046
GO:0110095
GO:0140041
GO:0140096
GO:0140104
GO:0140110
GO:0140297
GO:0140299
GO:1900182
GO:1901135
GO:1901671
GO:1901984
GO:1902176
GO:1902177
GO:1902236
GO:1902903
GO:1902958
GO:1903073
GO:1903094
GO:1903122
GO:1903135
GO:1903136
GO:1903168
GO:1903178
GO:1903181
GO:1903189
GO:1903190
GO:1903197
GO:1903200
GO:1903376
GO:1903377
GO:1903384
GO:1903427
GO:1903428
GO:1903599
GO:1903751
GO:1905259
GO:1990381
GO:1990422
GO:2000157
GO:2000379
GO:2000679
GO:2000825
GO:2001237
GO:2001268
HMNXSV003049397
ILMN_1744713
PH_hs_0025114
TC01000101.hg
TC09000477.hg
g6005748_3p_at
p33735
Participates
as a member of
Other forms of this molecule
monoSUMO1-K130-PARK7 [nucleoplasm]
PARK7 [nucleoplasm]
PolyUb-Misfolded PARK7 [late endosome lumen]
Misfolded PARK7 [cytosol]
Ub-Misfolded PARK7 [cytosol]
PolyUb-Misfolded PARK7 [cytosol]
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
L-leucine 166 replaced with L-proline
Coordinate
166
PsiMod
L-leucine removal [MOD:01641]
A protein modification that effectively removes or replaces an L-leucine.
L-proline residue [MOD:00024]
A protein modification that effectively converts a source amino acid residue to L-proline.
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
Interactors (33)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9UER7 DAXX  13 0.714 6
 UniProt:Q99497 PARK7  7 0.692 3
 UniProt:Q96FW1 OTUB1  2 0.666 4
 UniProt:Q8NFJ9 BBS1  1 0.666 4
 UniProt:Q13158 FADD  1 0.653 9
 UniProt:P13569 CFTR  17 0.615 16
 UniProt:P32322 PYCR1  1 0.61 5
 UniProt:P10275 AR  4 0.602 6
 UniProt:O94776 MTA2  1 0.576 3
 UniProt:P63244 RACK1  1 0.576 4
 UniProt:O14656-2 TOR1A      0.556 3
 UniProt:P50570-2 DNM2      0.556 3
 UniProt:Q6ZNA4-2 Q6ZNA42      0.556 3
 UniProt:P63010-2 AP2B1      0.556 3
 UniProt:P01023 A2M  2 0.556 3
 IntAct:EBI-25849442 CCSB      0.556 3
 UniProt:Q9HD26 GOPC  3 0.556 3
 UniProt:Q6DN90-2 Q6DN902      0.556 3
 UniProt:Q9ULX5 RN112      0.556 3
 UniProt:Q8NFH3 NUP43  2 0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:Q8N5S9-2 Q8N5S92      0.556 3
 UniProt:Q9GZS3 SKIC8  2 0.556 3
 UniProt:Q8IUW3 SPA2L      0.556 3
 UniProt:P06241-3 FYN      0.556 3
 UniProt:Q9BYQ4 KRTAP9-2  1 0.556 3
 UniProt:Q9UBQ0-2 VPS29      0.556 3
 UniProt:P42858 HTT  1 0.556 6
 UniProt:Q9BYZ2 LDHAL6B  1 0.556 3
 UniProt:Q13547 HDAC1  2 0.537 4
 UniProt:P00441 SOD1  5 0.527 2
 UniProt:Q6GQQ9 OTUD7B  1 0.524 3
 UniProt:P31483 TIA1  1 0.463 3
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