Reactome | HDAC6 [lysosomal lumen]

HDAC6 [lysosomal lumen]

Stable Identifier

R-HSA-9660002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

HDAC6_HUMAN

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Chaperone Mediated Autophagy (Homo sapiens)
  - HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        HDAC6 [lysosomal lumen] (Homo sapiens)
  - HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        HDAC6 [lysosomal lumen] (Homo sapiens)
    - HSPA8:Substrates for CMA [lysosomal lumen] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)
        
        HDAC6 [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBN7 HDAC6

Gene Names

HDAC6, KIAA0901, JM21

Chain

chain:1-1215

Reference Genes

BioGPS Gene:10013 HDAC6

COSMIC (genes):HDAC6 HDAC6

CTD Gene:10013 HDAC6

dbSNP Gene:10013 HDAC6

ENSEMBL:ENSG00000094631 HDAC6

ENSEMBL_homo_sapiens_GENE:ENSG00000094631.22 HDAC6

HGNC:14064 HDAC6

KEGG Gene (Homo sapiens):10013 HDAC6

Monarch:10013 HDAC6

NCBI Gene:10013 HDAC6

OMIM:300272 HDAC6

UCSC:Q9UBN7 HDAC6

Reference Transcript

Other Identifiers

10013

11725083_s_at

11748402_a_at

11750582_a_at

11751547_a_at

11754957_a_at

11756962_x_at

17103451

206846_PM_s_at

206846_s_at

216224_PM_s_at

216224_s_at

35795_at

3976849

3976850

3976851

3976852

3976853

3976854

3976855

3976856

3976857

3976858

3976859

3976860

3976861

3976862

3976863

3976864

3976866

3976868

3976870

3976871

3976875

3976876

3976879

3976881

3976883

3976884

3976885

3976886

3976887

3976888

3976889

3976891

3976893

3976894

3976895

3976896

3976899

3976900

3976901

3976902

3976903

3976904

3976905

3976907

3976908

3976909

3976910

8167369

A_23_P250455

A_33_P3320619

GE56783

GO:0000118

GO:0000122

GO:0000209

GO:0000978

GO:0001222

GO:0001932

GO:0001975

GO:0002376

GO:0003677

GO:0003779

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005771

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0005875

GO:0005886

GO:0005901

GO:0005929

GO:0006325

GO:0006351

GO:0006355

GO:0006476

GO:0006511

GO:0006515

GO:0006886

GO:0006914

GO:0007005

GO:0007010

GO:0007015

GO:0007018

GO:0007026

GO:0008013

GO:0008017

GO:0008092

GO:0008270

GO:0010506

GO:0010558

GO:0010634

GO:0010727

GO:0010821

GO:0010977

GO:0015630

GO:0016234

GO:0016235

GO:0016241

GO:0016575

GO:0016787

GO:0019213

GO:0019896

GO:0019899

GO:0023052

GO:0030154

GO:0030163

GO:0030182

GO:0030424

GO:0030425

GO:0031252

GO:0031333

GO:0031410

GO:0031593

GO:0031625

GO:0031647

GO:0031648

GO:0032418

GO:0032984

GO:0032991

GO:0033138

GO:0033558

GO:0034330

GO:0034605

GO:0034983

GO:0035902

GO:0035967

GO:0036064

GO:0036211

GO:0042826

GO:0042903

GO:0042995

GO:0043005

GO:0043014

GO:0043025

GO:0043130

GO:0043131

GO:0043162

GO:0043204

GO:0043226

GO:0043242

GO:0044782

GO:0045598

GO:0045814

GO:0045861

GO:0045892

GO:0046872

GO:0048156

GO:0048471

GO:0048487

GO:0048668

GO:0048843

GO:0048856

GO:0048870

GO:0050775

GO:0051354

GO:0051412

GO:0051646

GO:0051787

GO:0051788

GO:0051879

GO:0051968

GO:0060271

GO:0060632

GO:0060765

GO:0060997

GO:0061523

GO:0061734

GO:0065003

GO:0070201

GO:0070301

GO:0070507

GO:0070840

GO:0070842

GO:0070845

GO:0070848

GO:0071218

GO:0071374

GO:0071548

GO:0090042

GO:0090044

GO:0098779

GO:0140096

GO:1900409

GO:1901984

GO:1903146

GO:1904056

GO:1904115

GO:2000273

HMNXSV003006402

Hs.6764.2.S1_3p_a_at

ILMN_1798546

PH_hs_0000680

TC0X000261.hg

g13128863_3p_a_at

Participates

as a component of

PolyUb-Misfolded Proteins:HDAC6 [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

HDAC6 [nucleoplasm]

HDAC6 [late endosome lumen]

HDAC6 [cytosol]

Cross References

RefSeq

NP_001308157.1, NP_001308155.1, NP_001308158.1, NP_006035.2, NP_001308156.1

ZINC - World Drugs

HDAC6_HUMAN

Guide to Pharmacology - Targets

2618

OpenTargets

ENSG00000094631

ZINC - FDA approved

HDAC6_HUMAN

ZINC - Substances

HDAC6_HUMAN

ZINC - Biogenic

HDAC6_HUMAN

ZINC target

Q9UBN7

PRO

Q9UBN7

PDB

5KH3, 7ZYU, 6CE8, 3GV4, 8G45, 8G44, 6CED, 5EDU, 5WBN, 6CEC, 6CE6, 8G43, 5KH9, 5B8D, 6CEA, 3C5K, 5WPB, 3PHD, 6CEF, 5KH7, 6CEE

ZINC - Investigational

HDAC6_HUMAN

GeneCards

Q9UBN7

HPA

ENSG00000094631-HDAC6

Ensembl

ENSP00000402751, ENSP00000496013, ENSG00000094631, ENSP00000496046, ENSP00000365831, ENSP00000365795, ENST00000376619, ENST00000643374, ENSP00000334061, ENST00000423941, ENST00000644068, ENSP00000392815, ENST00000376643, ENST00000334136, ENSP00000365804, ENST00000440653, ENST00000443563, ENST00000376610, ENSP00000394377

Pharos - Targets

Q9UBN7

Orphanet

19581

ZINC - Predictions - Purchasable

HDAC6_HUMAN

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.809	12
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.721	5
UniProt:Q9Y263 PLAP			0.643	3
UniProt:P04610 TAT			0.631	11
UniProt:O60260 PARK2	4	polyUb-PARK2 [cytosol] (R-HSA-5689094) p-S9-PRKN [cytosol] (R-HSA-9793481) p-S65-PRKN [cytosol] (R-HSA-9834954) PRKN [cytosol] (R-HSA-201579)	0.602	6
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.602	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.593	3
UniProt:Q9NQC7 CYLD	3	K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664) p-S418-CYLD [cytosol] (R-HSA-5212667) CYLD [cytosol] (R-HSA-741420)	0.576	4
UniProt:O43490 PROM1			0.567	4
UniProt:P21146	4	phospho-p-S29-ADRBK1 [cytosol] (R-BTA-9645318) ADRBK1 [cilium] (R-BTA-5632504) phospho-p-S29-ADRBK1 [plasma membrane] (R-BTA-111969) GRK2 [plasma membrane] (R-BTA-50270)	0.558	3
UniProt:Q60598 Cttn	2	p-S113-Cttn [cytosol] (R-MMU-442839) Cttn [cytosol] (R-MMU-442836)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	6
UniProt:Q13148 TADBP			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.553	2
UniProt:P21860 ERBB3			0.553	2
UniProt:Q15303 ERBB4			0.553	2
UniProt:Q71U36 TUBA1A	9	AcK-TUBA1A [cytosol] (R-HSA-5618312) Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852) TUBA1A folding intermediate [cytosol] (R-HSA-392805) TUBA1A unfolded [cytosol] (R-HSA-392767) L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428) Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408) TUBA1A(1-450) [cytosol] (R-HSA-8955577) TUBA1A [cytosol] (R-HSA-191689) TUBA1A [axonemal microtubule] (R-HSA-5610433)	0.534	2
UniProt:O00295 TULP2			0.527	3
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:Q96S82 UBL7			0.527	2
UniProt:Q9BQK8 LPIN3	3	p-S106-LPIN3 [nucleoplasm] (R-HSA-4419935) LPIN3 [nuclear envelope] (R-HSA-4419928) LPIN3 [endoplasmic reticulum membrane] (R-HSA-549160)	0.527	2
UniProt:O43448 KCNAB3	1	KCNAB3 [plasma membrane] (R-HSA-1297367)	0.527	2
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.527	2
UniProt:P11182 DBT	11	DBT [cytosol] (R-HSA-9714663) I98M Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865057) Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) DBT [mitochondrial matrix] (R-HSA-6792584) P276C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865046) S399C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865036) K313_Y338del Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865051)	0.527	2
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.524	6
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.524	2
UniProt:Q62623	3	Cdc20 [nucleoplasm] (R-RNO-6783069) Cdc20 [nucleoplasm] (R-RNO-174112) Cdc20 [cytosol] (R-RNO-141412)	0.524	2
UniProt:Q9NQ11 ATP13A2	1	ATP13A2 [lysosomal lumen] (R-HSA-939762)	0.508	2
UniProt:Q9H9Y6 POLR1B	1	POLR1B [nucleoplasm] (R-HSA-63496)	0.488	2
UniProt:P03409 TAX			0.463	4
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.463	2
UniProt:P25098 GRK2	4	p-S29-ADRBK1 [cytosol] (R-HSA-9645318) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) GRK2 [plasma membrane] (R-HSA-50270)	0.463	2

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