S-GGC MRAS G23V [plasma membrane]

Stable Identifier
R-HSA-9660504
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Ras-related protein M-Ras, RASM_HUMAN
Icon
S-GGC MRAS G23V [plasma membrane] icon
S-GGC MRAS G23V [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
28289718 Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy

Tester, DJ, Sol-Church, K, Higgins, EM, MacRae, CA, Mason-Suares, H, Ackerman, JP, Bos, JM, Urrutia, R, Gripp, KW, Ackerman, MJ

JCI Insight 2017
External Reference Information
External Reference
UniProt:O14807 MRAS
Gene Names
MRAS, RRAS3
Chain
chain:1-205, propeptide:206-208
Reference Genes
BioGPS Gene:22808 MRAS
COSMIC (genes):MRAS MRAS
CTD Gene:22808 MRAS
dbSNP Gene:22808 MRAS
ENSEMBL:ENSG00000158186 MRAS
ENSEMBL_homo_sapiens_GENE:ENSG00000158186.13 MRAS
HGNC:7227 MRAS
KEGG Gene (Homo sapiens):22808 MRAS
Monarch:22808 MRAS
NCBI Gene:22808 MRAS
OMIM:608435 MRAS
UCSC:O14807 MRAS
Reference Transcript
Other Identifiers
11716971_a_at
11758360_s_at
11758561_s_at
16946159
206538_PM_at
206538_at
225185_PM_at
225185_at
22808
2644566
2644567
2644568
2644569
2644571
2644589
2644603
2644604
2644610
2644611
2644612
2644613
2644614
2644615
2644616
2644617
38540_at
57217_at
8082965
A_14_P112094
A_14_P112544
A_14_P131120
A_23_P377197
A_24_P88850
GE54384
GO:0000166
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005886
GO:0007010
GO:0007165
GO:0007265
GO:0016020
GO:0016787
GO:0019003
GO:0023052
GO:0030036
GO:0030742
GO:0098772
GO:1990830
HMNXSV003047674
Hs.7298.1.A1_3p_at
ILMN_1748881
PH_hs_0016853
TC03000744.hg
Participates
as a member of
Other forms of this molecule
S-GGC MRAS G23R [plasma membrane]
S-GGC MRAS T68I [plasma membrane]
S-GGC MRAS G23D [plasma membrane]
S-GGC MRAS [plasma membrane]
Modified Residues
Name
S-geranylgeranyl-L-cysteine (geranylgeranyl group) at 205
Coordinate
205
Modification
geranylgeranyl group
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Name
glycine 23 replaced with L-valine
Coordinate
23
PsiMod
L-valine residue [MOD:00029]
A protein modification that effectively converts a source amino acid residue to an L-valine.
glycine removal [MOD:01638]
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
Noonan syndrome DOID:3490 Turner's phenotype, karyotype normal (disorder)
Cross References
RefSeq
ClinGen
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
PDB
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