RAS:GTP binds RAL GDS proteins

Stable Identifier
Reaction [binding]
Homo sapiens
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RAL GDS and related family members RGL1, 2 and 3 are small GTPase proteins in the RAS family that act as effectors downstream of HRAS and other RAS proteins (reviewed in Ferro and Trabalzini, 2010; Gentry et al, 2014). RALGDS family members bind to HRAS in the GTP-bound state through the RALGDS Ras binding domains (RBDs) and acts as RAL A and RAL B-specific guanine nuclear exchange factors (GEFs) (Hofer et al, 1994; Spaargen et al, 1994; Kikuchi et al, 1994; Wolthius et al, 1996; Peterson et al, 1996; Shao et al, 2000; Ehrhardt et al, 2001; reviewed in Gentry et al, 2014).

Literature References
PubMed ID Title Journal Year
25219551 Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame

Gentry, LR, Martin, TD, Reiner, DJ, Der, CJ

Biochim. Biophys. Acta 2014
10869344 A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras

Shao, H, Andres, DA

J. Biol. Chem. 2000
20478380 RalGDS family members couple Ras to Ral signalling and that's not all

Ferro, E, Trabalzini, L

Cell. Signal. 2010
7809086 Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

Spaargaren, M, Bischoff, JR

Proc. Natl. Acad. Sci. U.S.A. 1994
8710374 RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein

Wolthuis, RM, Bauer, B, van 't Veer, LJ, De Vries-Smits, AM, Cool, RH, Spaargaren, M, Wittinghofer, A, Burgering, BM, Bos, JL

Oncogene 1996
8939933 Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1

Peterson, SN, Trabalzini, L, Brtva, TR, Fischer, T, Altschuler, DL, Martelli, P, Lapetina, EG, Der, CJ, White, GC

J. Biol. Chem. 1996
7972015 Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator

Hofer, F, Fields, S, Schneider, C, Martin, GS

Proc Natl Acad Sci U S A 1994
11313946 A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth

Ehrhardt, GR, Korherr, C, Wieler, JS, Knaus, M, Schrader, JW

Oncogene 2001
7935463 ralGDS family members interact with the effector loop of ras p21

Kikuchi, A, Demo, SD, Ye, ZH, Chen, YW, Williams, LT

Mol. Cell. Biol. 1994
Orthologous Events
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