Reactome | SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

Stable Identifier

R-HSA-9661799

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

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Bilirubin (BIL), the end product of heme catabolism, is taken up from the blood circulation into the liver. The organic anion transporting polypeptide (SLCO1B3, aka OATP-8, LST2, SLC21A8), localised on the basolateral (sinusoidal side) hepatocyte membrane, can mediate the uptake of BIL and various other lipophilic anions into the human liver (van de Steeg et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22232210	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver Nosková, L, Kmoch, S, al-Edreesi, M, Jirsa, M, Wagenaar, E, Sticová, E, Knisely, AS, van de Steeg, E, Schinkel, AH, de Waart, DR, Hřebíček, M, Hartmannová, H, van Esch, A, Kenworthy, KE, Oude Elferink, RP, Stranecký, V	J. Clin. Invest.	2012