ADAM17 binds Zn2+

Stable Identifier
R-HSA-9662773
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Golgi membrane
ReviewStatus
5/5
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ADAM17 binds Zn2+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A crystallography study revealed that disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) requires Zinc as a cofactor to function properly (Maskos et al. 1998).
Literature References
PubMed ID Title Journal Year
9520379 Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

Castner, BJ, Bourenkov, GP, Wolfson, MF, Petersen, M, Davis, R, Reddy, P, Fitzner, JN, Ellestad, GA, Huber, R, Bartunik, H, Fernandez-Catalan, C, Rauch, CT, Maskos, K, Paxton, RJ, Black, RA, Cerretti, DP, Bode, W, Clarke, HR, March, CJ

Proc. Natl. Acad. Sci. U.S.A. 1998
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Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-09-24)
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