Reactome | PLK2, MAPK14 phosphorylate ADAM17

PLK2, MAPK14 phosphorylate ADAM17

Stable Identifier

R-HSA-9662823

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        CD163 mediating an anti-inflammatory response (Homo sapiens)
        
        PLK2, MAPK14 phosphorylate ADAM17 (Homo sapiens)

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The phosphorylation of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) by PLK2 and MAPKs has been determined by direct and indirect experiments (Müllberg et al. 1993, Schwarz et al. 2014, Fan and Derynck 1999; Gechtman et al. 1999; Díaz-Rodríguez et al. 2002; Fan, Turck, and Derynck 2003 & Xu and Derynck 2010). Specifically, the phosphorylation at residues Thr735 (Díaz-Rodríguez et al. 2002 & Xu and Derynck 2010) and Ser819 is required for ectodomains shedding.

Literature References

PubMed ID	Title	Journal	Year
12621058	Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide Derynck, R, Fan, H, Turck, CW	J. Biol. Chem.	2003
24338472	Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding Tholey, A, Chalaris, A, Scheller, J, Schmidt, S, Rose-John, S, Schmidt-Arras, D, Köhler, K, Rabe, B, Will, O, Schwake, M, Schwarz, J, Koudelka, T, Boss, M	J. Biol. Chem.	2014
20188673	Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation Derynck, R, Xu, P	Mol. Cell	2010
12058067	Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding Yuste, L, Díaz-Rodríguez, E, Montero, JC, Esparís-Ogando, A, Pandiella, A	Mol. Biol. Cell	2002
10601018	Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades Fan, H, Derynck, R	EMBO J.	1999
10497257	The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading Raab, G, Gechtman, Z, Klagsbrun, M, Alonso, JL, Ingber, DE	J. Biol. Chem.	1999

Participants

Input

Output

Participates

as an event of

CD163 mediating an anti-inflammatory response (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of PLK2, MAPK14 [cytosol]

Physical Entity

PLK2, MAPK14 [cytosol] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Authored

Murillo, JI (2020-01-07)

Jassal, B (2020-01-07)

Reviewed

Gregory, DJ (2020-02-04)

Created

Murillo, JI (2019-09-24)