CD163 mediating an anti-inflammatory response

Stable Identifier
R-HSA-9662834
Type
Pathway
Species
Homo sapiens
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High expression of the membrane protein CD163 in macrophages is a characteristic of tissues responding to inflammation elicited either by an intracellular pathogen infection (such as Mycobacterium leprae or Leishmania spp.) or due to an acute or chronic inflammatory disorder. The soluble form of this molecule, sCD163, is considered to be a potential inflammation biomarker and a therapeutic target; sCD163 is formed from the increased shedding of CD163 mediated by the tumor necrosis factor-α (TNF-α) cleaving enzyme, ADAM17 (Etzerodt & Moestrup 2013, Silva et al. 2017). The biological function of sCD163 is not yet clear, although several possible functions have been proposed: opsonization of Staphylococcus aureus, inhibition of T-cell proliferation and inhibition of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) (Tran et al. 2005).

Literature References
PubMed ID Title Journal Year
28355218 sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis

Silva, RL, Santos, MB, Almeida, PL, Barros, TS, Magalhães, L, Cazzaniga, RA, Souza, PR, Luz, NF, França-Costa, J, Borges, VM, Lima-Junior, DS, Lipscomb, MW, Duthie, MS, Reed, SG, Almeida, RP, Jesus, AR

PLoS Negl Trop Dis 2017
15611130 The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression

Tran, NL, McDonough, WS, Savitch, BA, Sawyer, TF, Winkles, JA, Berens, ME

J. Biol. Chem. 2005
22900885 CD163 and inflammation: biological, diagnostic, and therapeutic aspects

Etzerodt, A, Moestrup, SK

Antioxid. Redox Signal. 2013
Participants
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Event Information
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
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