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BIL binds GSTA1, FABP1
Stable Identifier
R-HSA-9663511
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme degradation (Homo sapiens)
BIL binds GSTA1, FABP1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Upon entry into the hepatocyte, bilirubin (BIL) can bind to one of two cytosolic binding proteins; glutathione S-transferase A1 (GSTA1 aka ligandin, Y-protein), a major cytosolic protein that has both transport and detoxification functions or fatty acid-binding protein (FABP1 aka Z-protein) (Levi et al. 1969, Simons & Jagt 1980, Arias 2012). It is assumed GSTA1 transports BIL to the ER where it is detoxified by conjugation with a glucuronosyl moiety.
Literature References
PubMed ID
Title
Journal
Year
4980931
Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions
Gatmaitan, Z
,
Levi, AJ
,
Arias, IM
J. Clin. Invest.
1969
7372607
Bilirubin binding to human liver ligandin (glutathione S-transferase)
Simons, PC
,
Jagt, DL
J. Biol. Chem.
1980
Participants
Input
BIL [cytosol]
GSTA1, FABP1 [cytosol]
(Homo sapiens)
Output
BIL:GSTA1, FABP1 [cytosol]
(Homo sapiens)
Participates
as an event of
Heme degradation (Homo sapiens)
Orthologous Events
BIL binds GSTA1, FABP1 (Bos taurus)
BIL binds GSTA1, FABP1 (Caenorhabditis elegans)
BIL binds GSTA1, FABP1 (Canis familiaris)
BIL binds GSTA1, FABP1 (Danio rerio)
BIL binds GSTA1, FABP1 (Dictyostelium discoideum)
BIL binds GSTA1, FABP1 (Drosophila melanogaster)
BIL binds GSTA1, FABP1 (Gallus gallus)
BIL binds GSTA1, FABP1 (Mus musculus)
BIL binds GSTA1, FABP1 (Plasmodium falciparum)
BIL binds GSTA1, FABP1 (Rattus norvegicus)
BIL binds GSTA1, FABP1 (Sus scrofa)
BIL binds GSTA1, FABP1 (Xenopus tropicalis)
Authored
Jassal, B (2019-10-02)
Reviewed
D'Eustachio, P (2019-10-03)
Created
Jassal, B (2019-10-02)
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