IL10 gene produces IL10 protein

Stable Identifier
R-HSA-9664346
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, external side of plasma membrane
ReviewStatus
5/5
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IL10 gene produces IL10 protein
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The Interleukin 10 (IL10) gene is located at chromosome 1q31-32. It encodes for a protein with the same name that acts as a pleiotropic cytokine expressed primarily by monocytes and to a smaller degree by lymphocytes. IL10 down-regulates the expression of Th1 cytokines, MHC class II and costimulatory molecules on macrophages (Eskdale et al. 1997).
Literature References
PubMed ID Title Journal Year
9162098 Mapping of the human IL10 gene and further characterization of the 5' flanking sequence

Kube, D, Gallagher, G, Tesch, H, Eskdale, J

Immunogenetics 1997
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-S133-CREB1:IL10 gene [nucleoplasm] (Homo sapiens)
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
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