Leishmania phagocytosis

Stable Identifier
R-HSA-9664417
Type
Pathway
Species
Homo sapiens
Related Species
Leishmania mexicana, Leishmania major
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Leishmania phagocytosis
Click the image above or here to open this pathway in the Pathway Browser
The internalization mechanism of leishmania parasites depends on not only the dynamic nature of the parasite's surface, but whether it is a non infective (procyclic) or infective (metacyclic) promastigote or infective amastigote, and also its virulent nature (Ueno et al. 2012 & Lee et al. 2018). Host receptors reported to facilitate Leishmania internalization include the third complement receptor (CR3), first complement receptor (CR1), mannose receptor (MR), Fc gamma receptors (FCGRs) and fibronectin receptors (FNRs) (Ueno et al 2012). The route of entry to the macrophage can affect the fate of the Leishmania parasite (Ueno et al. 2012).
Literature References
PubMed ID Title Journal Year
22726697 Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival

Ueno, N, Wilson, ME

Trends Parasitol. 2012
23543768 The roles of complement receptor 3 and Fcγ receptors during Leishmania phagosome maturation

McDowell, MA, Ballhorn, W, Carter, CR, Wilson, ME, Jerde, CL, Harintho, M, Whitcomb, JP, Polando, R, Jones, B, Dixit, UG

J. Leukoc. Biol. 2013
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
phagocytosis (0006909)
Disease
Name Identifier Synonyms
cutaneous leishmaniasis DOID:9111 Asian Desert Cutaneous Leishmaniasis, Leproid leishmaniasis, diffuse cutaneous leishmaniasis
Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-22)
Cite Us!