Reactome | p-Y-ERBB2 G776S [plasma membrane]

p-Y-ERBB2 G776S [plasma membrane]

Stable Identifier

R-HSA-9664608

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y-ERBB2 Gly776Ser

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ERBB2 in Cancer (Homo sapiens)
    - Signaling by ERBB2 KD Mutants (Homo sapiens)
      - ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
      - Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
      - Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:SHC1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
      - Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)
      - RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
        
        Phosphorylated heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        p-6Y-ERBB2 KD mutants:Ligand-Activated p-ERBB3,(p-EGFR,p-ERBB4) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)
        
        p-Y-ERBB2 G776S [plasma membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
18039657	Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism Johnson, RC, Ding, J, Spiridonov, NA, Johnson, GR, Wong, L, Fan, YX	J. Biol. Chem.	2008

External Reference Information

External Reference

UniProt:P04626 ERBB2

Gene Names

ERBB2, HER2, MLN19, NEU, NGL

Chain

signal peptide:1-22, chain:23-1255

Reference Genes

BioGPS Gene:2064 ERBB2

COSMIC (genes):ERBB2 ERBB2

CTD Gene:2064 ERBB2

dbSNP Gene:2064 ERBB2

ENSEMBL:ENSG00000141736 ERBB2

HGNC:3430 ERBB2

KEGG:hsa:2064 ERBB2

Monarch:2064 ERBB2

NCBI Gene:2064 ERBB2

OMIM:164870 ERBB2

UCSC:P04626 ERBB2

Reference Transcript

Other Identifiers

11736472_a_at

11750611_a_at

11751416_a_at

11755005_a_at

11762165_x_at

16833839

1802_s_at

1901_s_at

2064

210930_3p_s_at

210930_PM_s_at

210930_s_at

216836_PM_s_at

216836_s_at

234354_PM_x_at

234354_x_at

33218_at

3720403

3720404

3720405

3720406

3720407

3720408

3720409

3720410

3720411

3720412

3720413

3720417

3720418

3720419

3720420

3720421

3720422

3720423

3720424

3720425

3720426

3720427

3720428

3720429

3720430

3720431

3720432

3720433

3720434

3720435

3720436

3720437

3720438

3720439

3720440

3720441

3720442

3720443

3720444

3720446

3720447

3720448

3720449

3720450

3720451

3720452

3720453

3720454

3720455

3720456

3720457

3720458

3720459

3720460

3720461

3720462

3720463

3720464

3720465

3720466

3720467

3720468

3720469

3720470

3720471

3720472

8006906

A_14_P101724

A_14_P126019

A_23_P89249

A_24_P284420

A_33_P3292596

GE57810

GE84906

GO:0001042

GO:0001934

GO:0002116

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006355

GO:0006468

GO:0007165

GO:0007166

GO:0007167

GO:0007169

GO:0007399

GO:0007422

GO:0007507

GO:0007528

GO:0008045

GO:0008283

GO:0008284

GO:0009925

GO:0010008

GO:0010628

GO:0010646

GO:0014044

GO:0015026

GO:0016020

GO:0016323

GO:0016324

GO:0016740

GO:0018108

GO:0019838

GO:0022008

GO:0023051

GO:0030154

GO:0030182

GO:0030307

GO:0030971

GO:0031410

GO:0031594

GO:0032587

GO:0032886

GO:0033080

GO:0033088

GO:0034330

GO:0035025

GO:0035556

GO:0038127

GO:0038133

GO:0038134

GO:0038135

GO:0038143

GO:0042060

GO:0042127

GO:0042552

GO:0042734

GO:0042802

GO:0042995

GO:0043066

GO:0043125

GO:0043209

GO:0043226

GO:0043235

GO:0043406

GO:0043410

GO:0043491

GO:0045727

GO:0045765

GO:0045785

GO:0045943

GO:0046982

GO:0048471

GO:0048709

GO:0048856

GO:0050679

GO:0060089

GO:0070372

GO:0071363

GO:0071364

GO:0071526

GO:0090314

GO:0099645

GO:0140096

HMNXSV003015366

HMNXSV003026104

HMNXSV003035749

HMNXSV003041168

HMNXSV003051404

Hs.241524.0.S1_3p_at

Hs.323910.2.A1_3p_a_at

ILMN_1717902

ILMN_1728761

ILMN_2352131

M12036_at

PH_hs_0021933

PH_hs_0037938

TC17000480.hg

X03363_s_at

g10181232_3p_a_at

g10181232_3p_at

g10181232_3p_x_at

Participates

as a member of

p-Y-ERBB2 KD mutants (ERBB3) [plasma membrane] (Homo sapiens)

Other forms of this molecule

ERBB2 G309E [plasma membrane]

ERBB2 G309A [plasma membrane]

ERBB2 S310F [plasma membrane]

ERBB2 S310Y [plasma membrane]

p-6Y-ERBB2 G309A [plasma membrane]

p-6Y-ERBB2 G309E [plasma membrane]

p-6Y-ERBB2 S310F [plasma membrane]

p-6Y-ERBB2 S310Y [plasma membrane]

p-Y-ERBB2 L755P [plasma membrane]

p-Y-ERBB2 I767M [plasma membrane]

p-Y-ERBB2 T798I [plasma membrane]

p-Y-ERBB2 Y772_A775dup [plasma membrane]

p-Y-ERBB2 T862A [plasma membrane]

p-Y-ERBB2 T798M [plasma membrane]

p-Y-ERBB2 H878Y [plasma membrane]

p-Y-ERBB2 V777L [plasma membrane]

p-Y-ERBB2 L755S [plasma membrane]

p-Y-ERBB2 V777E [plasma membrane]

p-Y-ERBB2 V777M [plasma membrane]

p-Y-ERBB2 L755M [plasma membrane]

p-Y-ERBB2 L755W [plasma membrane]

p-Y-ERBB2 T733I [plasma membrane]

p-Y-ERBB2 H878R [plasma membrane]

p-Y-ERBB2 L869R [plasma membrane]

p-Y-ERBB2 L869Q [plasma membrane]

p-Y-ERBB2 G776L [plasma membrane]

p-Y-ERBB2 G776V [plasma membrane]

p-Y-ERBB2 G776C [plasma membrane]

ERBB2 D769Y [plasma membrane]

ERBB2 L755P [plasma membrane]

ERBB2 V842I [plasma membrane]

ERBB2 H878Y [plasma membrane]

ERBB2 T798M [plasma membrane]

ERBB2 D769H [plasma membrane]

ERBB2 T862A [plasma membrane]

ERBB2 Y772_A775dup [plasma membrane]

ERBB2 L755S [plasma membrane]

ERBB2 I767M [plasma membrane]

ERBB2 V777L [plasma membrane]

ERBB2 D769N [plasma membrane]

ERBB2 T733I [plasma membrane]

ERBB2 V777M [plasma membrane]

ERBB2 V777E [plasma membrane]

ERBB2 L755W [plasma membrane]

ERBB2 L755M [plasma membrane]

ERBB2 H878R [plasma membrane]

ERBB2 V842E [plasma membrane]

ERBB2 T798I [plasma membrane]

ERBB2 R896C [plasma membrane]

ERBB2 G778_P780dup [plasma membrane]

ERBB2 R896H [plasma membrane]

ERBB2 G776S [plasma membrane]

ERBB2 L869R [plasma membrane]

ERBB2 L869Q [plasma membrane]

ERBB2 G776C [plasma membrane]

ERBB2 G776L [plasma membrane]

ERBB2 G776V [plasma membrane]

p-6Y-ERBB2 Y772_A775dup [plasma membrane]

p-6Y-ERBB2 V777L [plasma membrane]

p-6Y-ERBB2 H878Y [plasma membrane]

ERBB2 L755_T759del [plasma membrane]

p-6Y-ERBB2 R896C [plasma membrane]

p-6Y-ERBB2 V842I [plasma membrane]

p-6Y-ERBB2 I767M [plasma membrane]

p-6Y-ERBB2 T862A [plasma membrane]

p-6Y-ERBB2 D769H [plasma membrane]

p-6Y-ERBB2 T798I [plasma membrane]

p-6Y-ERBB2 L755P [plasma membrane]

p-6Y-ERBB2 G778_P780dup [plasma membrane]

p-6Y-ERBB2 L755S [plasma membrane]

p-6Y-ERBB2 T798M [plasma membrane]

p-6Y-ERBB2 D769Y [plasma membrane]

p-6Y-ERBB2 V777E [plasma membrane]

p-6Y-ERBB2 T733I [plasma membrane]

p-6Y-ERBB2 L755M [plasma membrane]

p-6Y-ERBB2 V777M [plasma membrane]

p-6Y-ERBB2 V842E [plasma membrane]

p-6Y-ERBB2 D769N [plasma membrane]

p-6Y-ERBB2 R896H [plasma membrane]

p-6Y-ERBB2 L755W [plasma membrane]

p-6Y-ERBB2 H878R [plasma membrane]

p-6Y-ERBB2 E693K [plasma membrane]

p-6Y-ERBB2 R677L [plasma membrane]

p-7Y,Y1112-ERBB2 [plasma membrane]

p-6Y,Y1112-ERBB2 [plasma membrane]

p-7Y-ERBB2 [plasma membrane]

p-6Y-ERBB2 [plasma membrane]

p-Y,Y877-ERBB2 [plasma membrane]

p-Y-ERBB2 [plasma membrane]

p-Y877-ERBB2 [plasma membrane]

ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]

p-6Y-ERBB2 S653C [plasma membrane]

p-6Y-ERBB2 R678Q [plasma membrane]

ERBB2 E693K [plasma membrane]

ERBB2 Q709L [plasma membrane]

ERBB2 V659K [plasma membrane]

ERBB2 G660D [plasma membrane]

ERBB2 V659E [plasma membrane]

ERBB2 G660R [plasma membrane]

ERBB2 R677L [plasma membrane]

ERBB2 S653C [plasma membrane]

ERBB2 R678Q [plasma membrane]

p-6Y-ERBB2 V659E [plasma membrane]

p-6Y-ERBB2 V659K [plasma membrane]

p-6Y-ERBB2 G660R [plasma membrane]

p-6Y-ERBB2 G660D [plasma membrane]

p-6Y-ERBB2 Q709L [plasma membrane]

Modified Residues

Name

glycine 776 replaced with L-serine

Coordinate

776

PsiMod

glycine removal [MOD:01638]

A protein modification that effectively removes or replaces an glycine.

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
bladder carcinoma	DOID:4007	carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
stomach cancer	DOID:10534	malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_001276867.1, NP_004439.2, NP_001005862.1, NP_001276865.1

ZINC - World Drugs

ERBB2_HUMAN

Guide to Pharmacology - Targets

2019

OpenTargets

ENSG00000141736

ENSEMBL

ENSP00000269571, ENST00000541774, ENST00000584601, ENST00000269571, ENSP00000462438, ENSP00000446466, ENSP00000385185, ENST00000406381

ZINC - FDA approved

ERBB2_HUMAN

ZINC - Substances

ERBB2_HUMAN

ZINC - Biogenic

ERBB2_HUMAN

ZINC target

P04626

PRO

P04626

PDB

6ATT, 3WSQ, 3WLW, 2N2A, 8PWH, 7PCD, 3PP0, 1QR1, 8U4K, 8HGP, 8U8X, 2A91, 2JWA, 5O4G, 4NND, 4HRM, 1MW4, 5TQS, 1N8Z, 4GFU, 8JYR, 5MY6, 6BGT, 7QVK, 8Q6J, 1MFL, 2L4K, 5K33, 5OB4, 8HGO, 7MN6, 7MN5, 6OGE, 8U4L, 2KS1, 1S78, 4HRN, 4HRL, 1MFG, 8FFJ, 3RCD, 8JYQ, 7MN8, 7JXH, 6LBX, 3N85, 3H3B, 3MZW, 6J71, 3BE1, 5KWG

ZINC - Investigational

ERBB2_HUMAN

ZINC - Metabolites

ERBB2_HUMAN

COSMIC

COSV54066483

HPA

ENSG00000141736-ERBB2

Pharos - Targets

P04626

ZINC - Predictions - Purchasable

ERBB2_HUMAN

HMDB Protein

HMDBP01473

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21860 ERBB3			0.973	30
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.954	25
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.926	12
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.916	8
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.856	6
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.821	16
UniProt:Q15303 ERBB4			0.816	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.793	5
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.779	5
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.775	9
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.759	12
UniProt:Q96JA1 LRIG1	2	Ub-LRIG1 [plasma membrane] (R-HSA-8875434) LRIG1 [plasma membrane] (R-HSA-197745)	0.748	7
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.708	11
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.702	8
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.695	5
UniProt:O95292 VAPB	2	VAPB [Golgi membrane] (R-HSA-9715115) VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.671	4
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124)	0.671	4
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.659	3
UniProt:Q9UJM3 ERRFI			0.659	4
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.643	3
UniProt:P0DTD8 NS7B			0.643	3
UniProt:Q13882 PTK6	5	PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103)	0.628	4
UniProt:P98172 EFNB1	2	p-Y324,Y329,Y343-EFNB1 [plasma membrane] (R-HSA-3928412) EFNB1 [plasma membrane] (R-HSA-2682327)	0.602	12
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.602	5
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.594	3
UniProt:Q9UQF2 JIP1			0.592	4
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.592	4
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.592	3
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.592	8
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.59	10
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.59	2
IntAct:EBI-4399559 UBIQ			0.589	2
UniProt:Q9HB71 CYBP			0.573	2
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.573	2
UniProt:P16885 PLCG2	8	p-PLCG2 [plasma membrane] (R-HSA-114602) PLCG2 [plasma membrane] (R-HSA-114601) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.571	3
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.571	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.571	2
UniProt:O60884 DNAJA2	1	DNAJA2 [cytosol] (R-HSA-3371555)	0.569	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	3
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.567	16
UniProt:Q15075 EEA1	1	EEA1 [endosome membrane] (R-HSA-187893)	0.567	5
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.567	14
UniProt:O14980 XPO1	2	XPO1 [cytosol] (R-HSA-165539) XPO1 [nucleoplasm] (R-HSA-165529)	0.564	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.558	2
UniProt:Q99952 PTPN18	2	PTPN18 [nucleoplasm] (R-HSA-9008900) PTPN18 [cytosol] (R-HSA-8864101)	0.558	6
UniProt:O95980 RECK	2	cleaved GPI-RECK [extracellular region] (R-HSA-8941046) GPI-RECK [plasma membrane] (R-HSA-8940687)	0.556	4
UniProt:O75367 H2AY			0.556	6
UniProt:Q9P2T1 GMPR2	1	GMPR2 [cytosol] (R-HSA-514631)	0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.553	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.553	2
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.547	2
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.547	2
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.537	10
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.536	2
UniProt:P31689 DNAJA1	2	SOH-C149,C150-DNAJA1 [cytosol] (R-HSA-9857072) DNAJA1 [cytosol] (R-HSA-3371544)	0.527	2
UniProt:P61619 SEC61A1	2	SEC61A1 [endoplasmic reticulum membrane] (R-HSA-444591) SEC61A1 [phagocytic vesicle membrane] (R-HSA-1236813)	0.527	2
UniProt:P36542 ATP5F1C	1	ATP5F1C [mitochondrial matrix] (R-HSA-164577)	0.527	2
UniProt:O00483 NDUFA4	1	NDUFA4 [mitochondrial inner membrane] (R-HSA-60617)	0.527	2
UniProt:O95573 ACSL3	2	ACSL3 [mitochondrial outer membrane] (R-HSA-9632656) ACSL3 [endoplasmic reticulum membrane] (R-HSA-548787)	0.527	2
UniProt:Q8WUY1 THEM6			0.527	2
UniProt:Q9NVI7 ATD3A			0.527	2
UniProt:P42704 LRPPRC	1	LRPPRC [mitochondrial matrix] (R-HSA-5336174)	0.527	2
UniProt:Q00325 S25A3			0.527	2
UniProt:Q9BVV7 TIMM21	2	TIMM21 [mitochondrial inner membrane] (R-HSA-1252042) TIMM21 [mitochondrial intermembrane space] (R-HSA-9865416)	0.527	2
UniProt:Q3ZCQ8 TIMM50	1	TIMM50 [mitochondrial inner membrane] (R-HSA-1252070)	0.527	2
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.527	3
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.527	2
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.525	2
UniProt:Q99952-1 PTPN18			0.524	5
IntAct:EBI-5590949 HAS			0.524	2
UniProt:Q15256 PTPRR			0.508	2
UniProt:P15309 ACP3	2	ACPP [plasma membrane] (R-HSA-3229238) ACPP [azurophil granule membrane] (R-HSA-6799214)	0.472	2
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.463	3

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