ATM dimer:PEX5 phosphorylates PEX5

Stable Identifier
R-HSA-9664862
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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ATM dimer:PEX5 phosphorylates PEX5
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When serine/threonine kinase Ataxia telangiectasia mutated protein (ATM) is activated it can phosphorylate Peroxisomal targeting signal 1 receptor protein (PEX5) at Ser141 (Zhang J et al. 2015).
Literature References
PubMed ID Title Journal Year
26344566 ATM functions at the peroxisome to induce pexophagy in response to ROS

Kim, J, Walker, CL, Pandita, TK, Charaka, VK, Jing, J, Dere, R, Zhang, J, Kastan, MB, Lee, JH, Alexander, A, Pandita, RK, Paull, TT, Tripathi, DN, Powell, RT, Tait-Mulder, J

Nat. Cell Biol. 2015
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Orthologous Events
ATM dimer:PEX5 phosphorylates PEX5 (Bos taurus)
ATM dimer:PEX5 phosphorylates PEX5 (Canis familiaris)
ATM dimer:PEX5 phosphorylates PEX5 (Dictyostelium discoideum)
ATM dimer:PEX5 phosphorylates PEX5 (Drosophila melanogaster)
ATM dimer:PEX5 phosphorylates PEX5 (Gallus gallus)
ATM dimer:PEX5 phosphorylates PEX5 (Mus musculus)
ATM dimer:PEX5 phosphorylates PEX5 (Rattus norvegicus)
ATM dimer:PEX5 phosphorylates PEX5 (Saccharomyces cerevisiae)
ATM dimer:PEX5 phosphorylates PEX5 (Schizosaccharomyces pombe)
ATM dimer:PEX5 phosphorylates PEX5 (Sus scrofa)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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