Reactome | NBR1 binds MAP1LC3B

NBR1 binds MAP1LC3B

Stable Identifier

R-HSA-9664867

Type

Reaction [binding]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

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Once recruited to the peroxisomal membrane, Next to BRCA1 gene 1 protein (NBR1) can bind with Microtubule associated proteins 1A/1B light chain 3B (MAP1LC3B)/LC3 with the help of its LC3 interacting region (LIR) domain (Kirkin V et al. 2009). This targets the peroxisomes to the autophagosomes and the degradation process starts.

Literature References

PubMed ID	Title	Journal	Year
19250911	A role for NBR1 in autophagosomal degradation of ubiquitinated substrates Komatsu, M, Sou, YS, Bilusic, I, Ishii, T, Wild, P, McEwan, DG, Øvervatn, A, Dikic, I, Elazar, Z, Bruun, JA, Lamark, T, Nunn, JL, Johansen, T, Clausen, TH, Kirkin, V, Shvets, E, Bjørkøy, G, Theurillat, JP	Mol. Cell	2009