After Peroxisomal targeting signal 1 receptor (PEX5) recruits Ataxia telangiectasia mutated protein (ATM) to the peroxisomal membrane, ATM is activated by the reactive oxygen species (ROS). ROS can oxidize and activate ATM by forming a disulphide cross-linked dimer at the Csy2991 residue (Guo Z et al. 2010).
Excess accumulation of reactive oxygen species in the cilium can result in the misfolding of cilia proteins leading to shortening of the cilia (Lam HC et al. 2013, Kim JI et al. 2013).