NBR1 binds ATM:Ub-p-PEX5:SQSTM1

Stable Identifier
R-HSA-9664881
Type
Reaction [binding]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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NBR1 binds ATM:Ub-p-PEX5:SQSTM1
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As autophagy receptors, Next to BRCA1 gene 1 protein (NBR1) and Sequestosome 1 (SQSTM1) can cooperate to achieve pexophagy. SQSTM1 supports NBR1 to bind ubiquitinated peroxisomes through its UBA domain and enhances the efficiency of the degradation process (Kirkin V et al. 2009).
Literature References
PubMed ID Title Journal Year
19398892 NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets

Lamark, T, Johansen, T, Kirkin, V, Dikic, I

Autophagy 2009
Participants
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Output
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Orthologous Events
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Bos taurus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Dictyostelium discoideum)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Gallus gallus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Mus musculus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Sus scrofa)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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