SQSTM1 binds ATM dimer:Ub-p-PEX5

Stable Identifier
R-HSA-9664892
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, peroxisomal membrane
ReviewStatus
5/5
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SQSTM1 binds ATM dimer:Ub-p-PEX5
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Sequestosome 1 (SQSTM1) is an autophagy adaptor that serves to bridge ubiquitinated cargo and the autophagosome. It binds ubiquitinated cargo via its UBA domain. SQSTM1 in the cytosol recognizes and binds with ubiquitinated Peroxisomal targeting signal 1 receptor (PEX5) in the peroxisomal membrane (Zhang et al. 2015).
Literature References
PubMed ID Title Journal Year
26344566 ATM functions at the peroxisome to induce pexophagy in response to ROS

Kim, J, Walker, CL, Pandita, TK, Charaka, VK, Jing, J, Dere, R, Zhang, J, Kastan, MB, Lee, JH, Alexander, A, Pandita, RK, Paull, TT, Tripathi, DN, Powell, RT, Tait-Mulder, J

Nat. Cell Biol. 2015
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Orthologous Events
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Bos taurus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Dictyostelium discoideum)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Drosophila melanogaster)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Gallus gallus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Mus musculus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Sus scrofa)
Authored
Varusai, TM  (2019-10-29)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-10-28)
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