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p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
Stable Identifier
R-HSA-9665380
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ERBB2 in Cancer (Homo sapiens)
Signaling by ERBB2 ECD mutants (Homo sapiens)
GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane] (Homo sapiens)
Participants
components
EGF:p-6Y-EGFR [plasma membrane]
(Homo sapiens)
p-6Y-ERBB2 ECD mutants [plasma membrane]
(Homo sapiens)
Participates
as a component of
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:SHC1 [plasma membrane] (Homo sapiens)
p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
as an input of
GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1 (Homo sapiens)
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1 (Homo sapiens)
as an output of
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 (Homo sapiens)
Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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