P2RX4,7 binds itself to form trimeric non-selective cation channels

Stable Identifier
R-HSA-9665515
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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P2RX4,7 binds itself to form trimeric non-selective cation channels
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At low to intermediate concentrations of extracellular ATP, P2X4 and P2X7 probably function as heterotrimeric, reversible ATP-gated, non-desensitizing cation channels (Markwardt 2007).
Literature References
PubMed ID Title Journal Year
11313357 Differential assembly of rat purinergic P2X7 receptor in immune cells of the brain and periphery

Surprenant, A, Spelta, V, Kim, M, Sim, J, North, RA

J Biol Chem 2001
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Authored
Murillo, JI  (2020-01-07)
Jassal, B  (2020-01-07)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2019-10-31)
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