AVPR1A,B bind desmopressin

Stable Identifier
R-HSA-9667456
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Desmopressin (trade name DDAVP) is a vasopressin receptor agonist drug used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. Desmopressin works by binding to arginine vasopressin receptors 1A and 1B (AVP1A,B) in the renal collecting duct (Saito et al. 1997, Derick et al. 2002). As a consequence, downstream signalling stimulates aquaporin channel translocation to the apical membrane of the collecting duct where they increase water reabsorption from urine (antidiuretic).

Literature References
PubMed ID Title Journal Year
12446593 [1-deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors

Szeto, HH, Stoev, S, Voirol, MJ, Guillon, G, Andres, M, Ben Mimoun, M, Wo, NC, Giacomini, M, Derick, S, Gaillard, RC, Cheng, LL, Manning, M

Endocrinology 2002
9264324 1-desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor

Sugimoto, T, Tahara, A, Saito, M

Biochem. Pharmacol. 1997
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!