AVPR1A,B,2 bind atosiban

Stable Identifier
R-HSA-9667619
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Atosiban (trade names Tractocile, Antocin, Atosiban SUN) is a nonapeptide, desamino-oxytocin analogue, competitive vasopressin/oxytocin receptor antagonist used as a labour repressant (tocolytic) to halt premature labour. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane resulting in reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells as well as reduced influx of Ca2+ from the extracellular space through voltage-gated channels. In addition, atosiban suppresses oxytocin-mediated release of prostaglandins PGE and PGF from the decidua (Sanu & Lamont 2010, Kim et al. 2019). Atosiban antagonises uterine contractions and induces uterine quiescence. (Akerlund et al. 1985, Bossmar et al. 1994).

Literature References
PubMed ID Title Journal Year
4061066 The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin

Carlsson, AM, Trojnar, J, Melin, P, Akerlund, M

Acta Obstet Gynecol Scand 1985
20463780 Critical appraisal and clinical utility of atosiban in the management of preterm labor

Lamont, RF, Sanu, O

Ther Clin Risk Manag 2010
30962532 Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F-induced Contractions and Inflammatory Responses in Human Myometrium

Bennett, PR, Terzidou, V, Chollet, A, Ahmed, H, Hanyaloglu, A, Riaposova, L, Pohl, O, Gotteland, JP, Kim, SH

Sci Rep 2019
7802081 Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of the oxytocin antagonist atosiban

Szamatowicz, J, Fantoni, G, Maggi, M, Melin, P, Bossmar, T, Akerlund, M

Am. J. Obstet. Gynecol. 1994
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