Reactome | SPAST [cytosol]

SPAST [cytosol]

Stable Identifier

R-HSA-9668426

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Spastin, fullName evidence="10 80"Spastin ecNumber evidence="10 37 40 45 48 50 65"5.6.1.1/ecNumber, SPAST_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P57740 NUP107

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External Reference Information

External Reference

UniProt:Q9UBP0 SPAST

Gene Names

SPAST, ADPSP, FSP2, KIAA1083, SPG4

Chain

chain:1-616

Reference Genes

BioGPS Gene:6683 SPAST

COSMIC (genes):SPAST SPAST

CTD Gene:6683 SPAST

dbSNP Gene:6683 SPAST

ENSEMBL:ENSG00000021574 SPAST

HGNC:11233 SPAST

KEGG:hsa:6683 SPAST

Monarch:6683 SPAST

NCBI Gene:6683 SPAST

OMIM:604277 SPAST

UCSC:Q9UBP0 SPAST

Reference Transcript

Participates

as an input of

SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as a component of

LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)

Inferred To

spas [cytosol] (Drosophila melanogaster)

Ghost homologue of SPAST [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of SPAST [cytosol] (Schizosaccharomyces pombe)

Spast [cytosol] (Mus musculus)

Spast [cytosol] (Rattus norvegicus)

spast [cytosol] (Danio rerio)

spast [cytosol] (Xenopus tropicalis)

SPAST [cytosol] (Bos taurus)

SPAST [cytosol] (Canis familiaris)

SPAST [cytosol] (Dictyostelium discoideum)

SPAST [cytosol] (Gallus gallus)

SPAST [cytosol] (Sus scrofa)

Homologues of SPAST [cytosol] (Sus scrofa)

spas-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_055761.2, NP_955468.1

OpenTargets

ENSG00000021574

ENSEMBL

ENSP00000320885, ENSP00000495015, ENST00000646571, ENSP00000496589, ENSP00000494312, ENSG00000021574, ENST00000315285, ENST00000642999, ENST00000644954

HPA

ENSG00000021574-SPAST

GeneCards

SPAST

PRO

Q9UBP0

Pharos - Targets

Q9UBP0

PDB

7S7J, 5Z6R, 5Z6Q, 6PEK, 6PEN, 3EAB, 3VFD

HMDB Protein

HMDBP11962

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WXF7-1 ATL1			0.593	4
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.591	3
UniProt:P53990 IST1	3	IST1 [cytosol] (R-HSA-9668516) IST1 [azurophil granule lumen] (R-HSA-6799169) IST1 [extracellular region] (R-HSA-6806231)	0.527	3
UniProt:P52948 NUP98			0.527	3
UniProt:Q9BW27 NUP85	2	NUP85 [nuclear envelope] (R-HSA-157741) NUP85 [cytosol] (R-HSA-376238)	0.527	2
UniProt:Q8WUM0 NUP133	2	NUP133 [nuclear envelope] (R-HSA-157743) NUP133 [cytosol] (R-HSA-376251)	0.527	3
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.527	2
UniProt:P57740 NUP107	2	NUP107 [nuclear envelope] (R-HSA-157717) NUP107 [cytosol] (R-HSA-376241)	0.527	3
UniProt:Q12769 NUP160	2	NUP160 [nuclear envelope] (R-HSA-157721) NUP160 [cytosol] (R-HSA-376253)	0.527	2
UniProt:Q5T4F4 ZFY27			0.463	3

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