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UFD1 [cytosol]
Stable Identifier
R-HSA-9668519
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UFD1L, Ubiquitin fusion degradation protein 1 homolog
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)
NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Homo sapiens)
NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Homo sapiens)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Homo sapiens)
NPLOC4:UFD1 [cytosol] (Homo sapiens)
UFD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92890 UFD1L
Gene Names
UFD1L, UFD1
Chain
chain:1-307
Reference Genes
BioGPS Gene:7353 UFD1L
COSMIC (genes):UFD1 UFD1L
CTD Gene:7353 UFD1L
dbSNP Gene:7353 UFD1L
ENSEMBL:ENSG00000070010 UFD1L
HGNC:12520 UFD1L
KEGG:hsa:7353 UFD1L
Monarch:7353 UFD1L
NCBI Gene:7353 UFD1L
OMIM:601754 UFD1L
UCSC:Q92890 UFD1L
Reference Transcript
RefSeq:NM_001035247.2 UFD1L
RefSeq:NM_005659.6 UFD1L
Other Identifiers
11715870_a_at
11715871_a_at
16932300
209103_PM_s_at
209103_s_at
3802384
3802385
3802393
3952719
3952720
3952721
3952722
3952723
3952724
3952725
3952726
3952727
3952728
3952729
3952730
3952731
3952732
3952736
3952737
3952738
3952739
3952740
3952741
3952743
3952744
3952745
3952747
3952748
68205_at
7353
78693_at
8074464
811_at
83970_at
A_23_P166333
A_33_P3265704
GE62181
GO:0001501
GO:0003824
GO:0004843
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006511
GO:0006886
GO:0010498
GO:0016787
GO:0030163
GO:0030970
GO:0031593
GO:0032480
GO:0034098
GO:0036435
GO:0036501
GO:0036503
GO:0039536
GO:0043161
GO:0043226
GO:0048856
GO:0071218
GO:0140096
HMNXSV003049013
HMNXSV003057057
ILMN_1665737
ILMN_2367458
PH_hs_0024633
TC22000496.hg
U64444_at
g12654446_3p_a_at
Participates
as a component of
NPLOC4:UFD1 [cytosol] (Homo sapiens)
Other forms of this molecule
UFD1L [nucleoplasm]
Inferred To
ufd-1 [cytosol]
(Caenorhabditis elegans)
Ufd1 [cytosol]
(Drosophila melanogaster)
Ufd1 [cytosol]
(Mus musculus)
Ufd1 [cytosol]
(Rattus norvegicus)
Ufd1l [cytosol]
(Gallus gallus)
ufd1l [cytosol]
(Danio rerio)
UFD1 [cytosol]
(Bos taurus)
UFD1 [cytosol]
(Canis familiaris)
UFD1 [cytosol]
(Plasmodium falciparum)
UFD1 [cytosol]
(Saccharomyces cerevisiae)
UFD1 [cytosol]
(Sus scrofa)
ufd1 [cytosol]
(Dictyostelium discoideum)
ufd1 [cytosol]
(Schizosaccharomyces pombe)
ufd1 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000263202
,
ENST00000263202
,
ENSP00000382439
,
ENST00000399523
OpenTargets
ENSG00000070010
HPA
ENSG00000070010-UFD1
PRO
Q92890
Pharos - Targets
Q92890
GlyGen
Q92890
Orphanet
UFD1
PDB
7WWQ
,
5B6C
,
2YUJ
,
5C1B
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.845
8
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
7
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
3
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