Reactome | RCC1 [chromosome]

RCC1 [chromosome]

Stable Identifier

R-HSA-9668547

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

chromosome

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Postmitotic nuclear pore complex (NPC) reformation (Homo sapiens)
        
        RCC1 stimulates GDP to GTP exchange on RAN (Homo sapiens)
        
        RCC1 [chromosome] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18754 RCC1

Gene Names

RCC1, CHC1

Chain

initiator methionine:, chain:2-421

Reference Genes

BioGPS Gene:1104 RCC1

COSMIC (genes):RCC1 RCC1

CTD Gene:1104 RCC1

dbSNP Gene:1104 RCC1

ENSEMBL:ENSG00000180198 RCC1

HGNC:1913 RCC1

KEGG:hsa:1104 RCC1

Monarch:1104 RCC1

NCBI Gene:1104 RCC1

OMIM:179710 RCC1

UCSC:P18754 RCC1

Reference Transcript

Other Identifiers

1104

11739421_a_at

11741252_a_at

1196_at

16661589

206499_PM_s_at

206499_s_at

215747_PM_s_at

215747_s_at

2327483

2327487

2327491

2327498

2327500

2327501

2327503

2327504

2327505

2327506

2327507

2327508

2327509

2327510

2327511

2327512

2327513

2327514

2327515

2327516

2327517

2327518

2327519

2327520

2327521

2327522

37927_at

7899462

A_14_P120765

A_23_P46309

A_24_P930442

D00591_at

GE59704

GO:0000082

GO:0000228

GO:0000785

GO:0000794

GO:0003677

GO:0003682

GO:0005085

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0007010

GO:0007052

GO:0007059

GO:0007084

GO:0007088

GO:0016032

GO:0031267

GO:0031491

GO:0031492

GO:0032991

GO:0042393

GO:0043199

GO:0043226

GO:0046982

GO:0051225

GO:0051301

GO:0061024

GO:0098772

HMNXSV003030318

Hs.84746.2.S1_3p_a_at

ILMN_1707493

ILMN_2311497

ILMN_2354211

PH_hs_0030839

PH_hs_0032120

TC01000381.hg

TC01004267.hg

g4502800_3p_a_at

Other forms of this molecule

RCC1 [nucleoplasm]

Inferred To

ran-3 [chromosome] (Caenorhabditis elegans)

RCC1 [chromosome] (Bos taurus)

RCC1 [chromosome] (Canis familiaris)

RCC1 [chromosome] (Dictyostelium discoideum)

RCC1 [chromosome] (Gallus gallus)

RCC1 [chromosome] (Plasmodium falciparum)

RCC1 [chromosome] (Sus scrofa)

pim1 [chromosome] (Schizosaccharomyces pombe)

rcc1 [chromosome] (Danio rerio)

rcc1 [chromosome] (Xenopus tropicalis)

SRM1 [chromosome] (Saccharomyces cerevisiae)

Rcc1 [chromosome] (Drosophila melanogaster)

Rcc1 [chromosome] (Mus musculus)

Rcc1 [chromosome] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000180198

ENSEMBL

ENST00000373833, ENST00000373832, ENSP00000508074, ENST00000398958, ENST00000373831, ENST00000683442, ENSP00000362939, ENSP00000362938, ENSP00000362937, ENSP00000381931, ENSG00000180198, ENST00000649185, ENSP00000497402

HPA

ENSG00000180198-RCC1

GeneCards

RCC1

PRO

P18754

Pharos - Targets

P18754

GlyGen

P18754

HMDB Protein

HMDBP08535

PDB

5TBK, 5E1D, 1I2M, 5E1B, 5E2B, 6DUB, 8UX1, 1A12, 5E1O, 5E2A, 5E1M

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.946	19
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.643	3
GDP [ChEBI:17552]	7	GDP [lysosomal membrane] (R-ALL-9628545) GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [cilium] (R-ALL-5617810) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [nucleoplasm] (R-ALL-111349) GDP [plasma membrane] (R-ALL-114549) GDP [endoplasmic reticulum lumen] (R-ALL-1467290)	0.623	2
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:O14980 XPO1	2	XPO1 [cytosol] (R-HSA-165539) XPO1 [nucleoplasm] (R-HSA-165529)	0.564	2
UniProt:Q9BV86 NTM1A			0.558	4
UniProt:P43487 RANBP1	1	RANBP1 [nuclear envelope] (R-HSA-167651)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	3
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.527	3
UniProt:Q9H6Z4 RANB3			0.508	2
UniProt:P02281 H2B11			0.499	2
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.488	3

Cite Us!