DNA polymerase:primase binds G-strand of the telomere

Stable Identifier
R-HSA-9668597
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DNA polymerase:primase binds G-strand of the telomere
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Binding of the polymerase alpha complex and the CST (Ctc1-Stn1-Ten1) complex to the telomeric DNA ends inhibits further extension of the G-strand by telomerase. The loading of the DNA polymerase alpha to telomeres does not depend on the CST complex, but the CST complex is needed for cessation of telomerase activity and for synthesis of RNA primers by the primase component of the DNA polymerase alpha (Feng et al. 2018. Gu et al. 2018).
Literature References
PubMed ID Title Journal Year
29774655 CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length

Smith, E, Takasugi, T, Hendrickson, E, Gu, P, Chang, S, Nandakumar, J, Jia, S

Aging Cell 2018
30026550 CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells

Diao, J, Price, CM, Feng, X, Bhattacharjee, A, Hsu, SJ, Wang, Y

Nat Commun 2018
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Orthologous Events
DNA polymerase:primase binds G-strand of the telomere (Bos taurus)
DNA polymerase:primase binds G-strand of the telomere (Canis familiaris)
DNA polymerase:primase binds G-strand of the telomere (Mus musculus)
DNA polymerase:primase binds G-strand of the telomere (Rattus norvegicus)
DNA polymerase:primase binds G-strand of the telomere (Sus scrofa)
Authored
Orlic-Milacic, M  (2019-12-18)
Reviewed
Hayashi, MT  (2020-04-29)
Created
Orlic-Milacic, M  (2019-11-28)
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