Reactome | STN1 [nucleoplasm]

STN1 [nucleoplasm]

Stable Identifier

R-HSA-9668821

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CST complex subunit STN1, STN1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8TCE9 PPL13

Expand all

Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Telomere C-strand synthesis initiation (Homo sapiens)
        
        CST complex formation (Homo sapiens)
        
        STN1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H668 STN1

Gene Names

STN1, OBFC1

Chain

chain:1-368

Reference Genes

BioGPS Gene:79991 STN1

COSMIC (genes):STN1 STN1

CTD Gene:79991 STN1

dbSNP Gene:79991 STN1

ENSEMBL:ENSG00000107960 STN1

ENSEMBL_homo_sapiens_GENE:ENSG00000107960.12 STN1

HGNC:26200 STN1

KEGG Gene (Homo sapiens):79991 STN1

Monarch:79991 STN1

NCBI Gene:79991 STN1

OMIM:613128 STN1

UCSC:Q9H668 STN1

Reference Transcript

Other Identifiers

11722652_at

11722653_a_at

16718106

219100_PM_at

219100_at

228781_PM_at

228781_at

3304984

3304994

3304996

3304997

3304999

3305000

3305001

3305002

3305004

3305006

3305008

3305010

3305012

3305014

3305016

3305018

3305019

3305020

3305021

3305022

3305026

3305027

3305028

3305032

3305034

3305035

3305036

3305038

3305042

3305045

3305046

3305047

3305048

3305049

3305050

3305051

54050_at

57666_at

58356_at

58359_g_at

60055_at

62389_at

7936134

79991

A_24_P759674

GE625806

GO:0000723

GO:0000781

GO:0001650

GO:0003676

GO:0003677

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005856

GO:0006260

GO:0006807

GO:0010833

GO:0016233

GO:0032200

GO:0032211

GO:0042162

GO:0043047

GO:0043170

GO:0043226

GO:0043229

GO:0043231

GO:0044238

GO:0045111

GO:0045740

GO:1990879

HMNXSV003043268

HMNXSV003054385

Hs.62314.0.A1_3p_at

ILMN_1789186

ILMN_1823851

ILMN_1906158

PH_hs_0014107

TC10001636.hg

TC10002814.hg

g13487922_3p_at

p1723

Participates

as an input of

CST complex formation (Homo sapiens)

as a component of

CST complex [nucleoplasm] (Homo sapiens)

Inferred To

Stn1 [nucleoplasm] (Mus musculus)

Stn1 [nucleoplasm] (Rattus norvegicus)

stn1 [nucleoplasm] (Danio rerio)

STN1 [nucleoplasm] (Bos taurus)

STN1 [nucleoplasm] (Canis familiaris)

STN1 [nucleoplasm] (Gallus gallus)

STN1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_006718039.1, XP_016872159.1, NP_079204.2, XP_016872158.1

OpenTargets

ENSG00000107960

GeneCards

Q9H668

HPA

ENSG00000107960-STN1

Ensembl

ENST00000224950, ENSP00000513621, ENSP00000513664, ENST00000698242, ENST00000698297, ENSP00000224950, ENSG00000107960, ENSP00000358779, ENST00000698243, ENST00000698304, ENST00000698298, ENST00000698241, ENST00000369764, ENSP00000513623, ENSP00000513622, ENSP00000513658, ENSP00000513657

PRO

Q9H668

Pharos - Targets

Q9H668

Orphanet

22123

PDB

8D0K, 4JQF, 6W6W, 8SOK, 8SOJ, 7U5C, 8D0B, 4JOI

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097) LDLRAP1 [plasma membrane] (R-HSA-171143)	0.887	13
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.876	13
UniProt:Q2NKJ3 CTC1	1	CTC1 [nucleoplasm] (R-HSA-9668825)	0.774	9
UniProt:Q9NWQ9 CN119			0.601	4
UniProt:Q2NKJ3-1 CTC1			0.593	5
IntAct:EBI-9009305 TELG31			0.558	2
UniProt:Q9NX04 AIRIM			0.556	5
UniProt:Q8TCE9 PPL13			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q8N7C3 TRIMM			0.556	3
UniProt:Q9P2K3-2 RCOR3			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q9BT92 TCHP			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q9UF02 CCG5			0.527	2
UniProt:O14773-1 TPP1			0.527	2
UniProt:Q96C01 F136A			0.527	3
UniProt:Q14181 POLA2	1	POLA2 [nucleoplasm] (R-HSA-68493)	0.527	2
UniProt:Q69YQ0 CYTSA			0.527	2
UniProt:Q8IY18 SMC5	1	SMC5 [nucleoplasm] (R-HSA-2993751)	0.527	2
UniProt:Q8WV22 NSMCE1	1	NSMCE1 [nucleoplasm] (R-HSA-2993767)	0.527	2
UniProt:Q01664 TFAP4			0.527	2
UniProt:Q9Y2B0 CNPY2			0.527	2
UniProt:A2RU48 SMCO3			0.527	2
UniProt:Q9C0K3 ARP3C			0.527	2
UniProt:Q96K76 USP47	1	USP47 [nucleoplasm] (R-HSA-5696961)	0.527	2
UniProt:Q9UFC0 LRWD1			0.527	2
UniProt:Q96MG7 NSMCE3	1	NSMCE3 [nucleoplasm] (R-HSA-2993761)	0.527	2
UniProt:Q9Y496 KIF3A	3	KIF3A [cilium] (R-HSA-5610394) KIF3A [cytosol] (R-HSA-984767) KIF3A [ciliary tip] (R-HSA-5625377)	0.527	2
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.527	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	4
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2

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