GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672158
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PDGFRA Y288C and PDGFRA del375-455 signal through the RAS-MAPK kinase cascade, as assessed by the presence of phosphorylated MAPK3 and MAPK1 (ERK1 and ERK2, respectively) by Western blot analysis. Although it has not been examined in detail, it is likely this occurs through the recruitment of GRB:SOS as is the case for the wild-type receptor (Ozawa et al, 2010; Ip et al, 2018).
Literature References
PubMed ID Title Journal Year
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Vellano, CP, Scott, KL, Ju, Z, Jeong, KJ, Shao, SH, Leonard, PG, Woessner, R, Mills, GB, Sahni, N, Ip, CKM, Hua, X, Ng, PKS

Nat Commun 2018
20889717 PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Ladanyi, M, Fomchenko, EI, Fujii, K, Brennan, CW, Tandon, A, Oka, H, Yasui, Y, Nakada, M, Wang, L, Sasayama, T, Holland, EC, Levine, RL, Pedraza, A, Utsuki, S, Huse, JT, Ozawa, T, Squatrito, M

Genes Dev. 2010
Participants
Input
Output
Participates
as an event of
Functional status

Gain of function of p-11Y PDGFRA extracellular domain dimers [endoplasmic reticulum membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2020-02-25)
Reviewed
Ip, CKM  (2020-02-06)
Created
Rothfels, K  (2019-12-23)
Cite Us!