PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers

Stable Identifier
R-HSA-9672162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers
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Gain-of-function extracellular domain mutants of PDGFRA signal through the PI3K/AKT signaling pathway as assessed by the increase in phosphorylated AKT, although all the pathway steps have not been directly demonstrated (Ozawa et al, 2010; Ip et al, 2018).
Literature References
PubMed ID Title Journal Year
30389923 Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Vellano, CP, Scott, KL, Ju, Z, Jeong, KJ, Shao, SH, Leonard, PG, Woessner, R, Mills, GB, Sahni, N, Ip, CKM, Hua, X, Ng, PKS

Nat Commun 2018
20889717 PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

Ladanyi, M, Fomchenko, EI, Fujii, K, Brennan, CW, Tandon, A, Oka, H, Yasui, Y, Nakada, M, Wang, L, Sasayama, T, Holland, EC, Levine, RL, Pedraza, A, Utsuki, S, Huse, JT, Ozawa, T, Squatrito, M

Genes Dev. 2010
Participants
Input
Output
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as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane]

Physical Entity
p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Functional status

Gain of function of p-11Y PDGFRA extracellular domain dimers:PI3K [endoplasmic reticulum membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Rhea
Authored
Rothfels, K  (2020-02-25)
Reviewed
Ip, CKM  (2020-02-06)
Created
Rothfels, K  (2019-12-23)
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