Gain-of-function mutants of PDGFRA bind to phosphatidylinositol-3' kinase (PI3K) to activate AKT signaling, as assessed by the presence of phosphorylated AKT in Western blot analysis (Heinrich et al, 2003; Ohashi et al, 2004; reviewed in Corless et al, 2011). Interaction of PI3K with mutant PDGFRA receptors is assumed to occur through binding to phosphorylated Y731 and Y742 as is the case for the wild-type receptor, although this hasn't been directly demonstrated (reviewed in Roskoski, 2018).
Barnett, CM, Corless, CL, Heinrich, MC
Roskoski, R
Kitamura, Y, Shinomura, Y, Isozaki, K, Nishida, T, Kinoshita, K, Ohashi, A, Hirota, S
Corless, CL, Heinrich, MC, Singer, S, Griffith, DJ, Town, A, Haley, A, Duensing, A, McGreevey, L, Fletcher, JA, Demetri, GD, Joseph, N, Chen, CJ, Fletcher, CD
Gain of function of p-11Y PDGFR mutant receptor dimers [plasma membrane]
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