GTP-bound RAC1 contributes to MAPK8 activation

Stable Identifier
R-HSA-9673284
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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GTP-bound RAC1 contributes to MAPK8 activation
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Ras-related C3 botulinum toxin substrate 1 (RAC1) activation was described as essential for p75NTR to induce MAPK8 (aka JNK) and apoptosis in cortical oligodendrocytes (Bazenet et al. 1998). The simultaneous activation of TRKA counteracts the apoptotic action of p75, by modulating the kinetics of p75-mediated RAC activation.
Literature References
PubMed ID Title Journal Year
9520479 The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

Bazenet, CE, Mota, MA, Rubin, LL

Proc Natl Acad Sci U S A 1998
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Catalyst Activity

protein kinase activity of WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane]

Physical Entity
WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane] (Homo sapiens)
Activity
protein kinase activity (GO:0004672)
Authored
Jassal, B  (2020-01-07)
Murillo, JI  (2019-10-22)
Reviewed
Gregory, DJ  (2020-02-04)
Created
Murillo, JI  (2020-01-07)
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