Ras-related C3 botulinum toxin substrate 1 (RAC1) activation was described as essential for p75NTR to induce MAPK8 (aka JNK) and apoptosis in cortical oligodendrocytes (Bazenet et al. 1998). The simultaneous activation of TRKA counteracts the apoptotic action of p75, by modulating the kinetics of p75-mediated RAC activation.
Bazenet, CE, Mota, MA, Rubin, LL
protein kinase activity of WNT5:FZD7:pp-DVL:RAC1:GTP [plasma membrane]
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