p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]

Stable Identifier
R-HSA-9673621
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
15070659 The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management

Gotlib, J, Cools, J, Malone, JM, Schrier, SL, Gilliland, DG, Coutré, SE

Blood 2004
12660384 A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

Cools, J, Deangelo, DJ, Gotlib, J, Stover, EH, Legare, RD, Cortes, J, Kutok, J, Clark, J, Galinsky, I, Griffin, JD, Cross, NC, Tefferi, A, Malone, J, Alam, R, Schrier, SL, Schmid, J, Rose, M, Vandenberghe, P, Verhoef, G, Boogaerts, M, Wlodarska, I, Kantarjian, H, Marynen, P, Coutré, SE, Stone, R, Gilliland, DG

N. Engl. J. Med. 2003
External Reference Information
External Reference
UniProt:Q6UN15 FIP1L1
Gene Names
FIP1L1, FIP1, RHE
Chain
chain:1-594
Reference Genes
BioGPS Gene:81608 FIP1L1
COSMIC (genes):FIP1L1 FIP1L1
CTD Gene:81608 FIP1L1
dbSNP Gene:81608 FIP1L1
ENSEMBL:ENSG00000145216 FIP1L1
HGNC:19124 FIP1L1
KEGG:hsa:81608 FIP1L1
Monarch:81608 FIP1L1
NCBI Gene:81608 FIP1L1
OMIM:607686 FIP1L1
UCSC:Q6UN15 FIP1L1
Reference Transcript
Participates
as a component of
Other forms of this molecule
FIP1L1 [nucleoplasm]
FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]
FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]
Modified Residues
Name
Replacement of residues 392 to 392 by GDCY
Name
Insertion of residues 585 to 1089 at 393 from UniProt:P16234 PDGFRA
Coordinate
393
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
hypereosinophilic syndrome DOID:999 Eosinophilic leukocytosis, eosinophilia
Cross References
RefSeq
OpenTargets
ENSEMBL
Mondo
HPA
GeneCards
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (15)
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