Reactome | p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]

p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]

Stable Identifier

R-HSA-9673636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Vascular endothelial growth factor receptor 2, VGFR2_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
20889717	PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas Ladanyi, M, Fomchenko, EI, Fujii, K, Brennan, CW, Tandon, A, Oka, H, Yasui, Y, Nakada, M, Wang, L, Sasayama, T, Holland, EC, Levine, RL, Pedraza, A, Utsuki, S, Huse, JT, Ozawa, T, Squatrito, M	Genes Dev.	2010

External Reference Information

External Reference

UniProt:P35968 KDR

Gene Names

KDR, FLK1, VEGFR2

Chain

signal peptide:1-19, chain:20-1356

Reference Genes

BioGPS Gene:3791 KDR

COSMIC (genes):KDR KDR

CTD Gene:3791 KDR

dbSNP Gene:3791 KDR

ENSEMBL:ENSG00000128052 KDR

HGNC:6307 KDR

KEGG:hsa:3791 KDR

Monarch:3791 KDR

NCBI Gene:3791 KDR

OMIM:191306 KDR

UCSC:P35968 KDR

Reference Transcript

RefSeq:NM_002253.2 KDR

Other Identifiers

11739315_at

11739316_at

16976029

1954_at

203934_PM_at

203934_at

2769811

2769812

2769813

2769814

2769815

2769816

2769817

2769818

2769819

2769820

2769821

2769822

2769824

2769825

2769826

2769827

2769828

2769831

2769832

2769833

2769834

2769835

2769837

2769838

2769839

2769840

2769842

2769845

2769848

2769849

2769850

2769851

2769852

2769853

2769856

2769857

2769860

2769861

2769862

2769863

3791

690_s_at

8100393

A_23_P58419

A_24_P71973

GE54268

GO:0001525

GO:0001541

GO:0001569

GO:0001570

GO:0001934

GO:0001938

GO:0001945

GO:0002042

GO:0002053

GO:0002070

GO:0003157

GO:0003158

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005021

GO:0005178

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005783

GO:0005794

GO:0005886

GO:0006468

GO:0007169

GO:0008284

GO:0008360

GO:0009897

GO:0009986

GO:0010463

GO:0010595

GO:0010629

GO:0015026

GO:0016020

GO:0016239

GO:0016477

GO:0016740

GO:0018108

GO:0019838

GO:0030054

GO:0030097

GO:0030154

GO:0030324

GO:0030335

GO:0030513

GO:0031401

GO:0031410

GO:0035162

GO:0035924

GO:0036324

GO:0038083

GO:0038084

GO:0038085

GO:0042802

GO:0043129

GO:0043226

GO:0043235

GO:0043408

GO:0043410

GO:0043524

GO:0043536

GO:0045121

GO:0045165

GO:0045296

GO:0045446

GO:0045766

GO:0045937

GO:0046777

GO:0048010

GO:0048286

GO:0048597

GO:0048754

GO:0048856

GO:0048870

GO:0050673

GO:0050679

GO:0050927

GO:0051770

GO:0051879

GO:0051894

GO:0051897

GO:0051901

GO:0055074

GO:0060089

GO:0060837

GO:0061042

GO:0070161

GO:0070374

GO:0071526

GO:0071944

GO:0072089

GO:0090050

GO:0090141

GO:0097443

GO:0140096

GO:1901532

GO:1903010

GO:1904881

GO:2000352

GO:2000648

GO:2001028

GO:2001214

HMNXSV003003815

ILMN_1686405

L04947_at

PH_hs_0001165

TC04001208.hg

g11321596_3p_at

Participates

as a component of

p-11Y VEGFR2(20-674)-PDGFRA(471-1089) fusion dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-6Y-VEGFR2 [plasma membrane]

VEGFR2 [plasma membrane]

p-Y801,Y1054,Y1175-KDR [plasma membrane]

VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]

Modified Residues

Name

Replacement of residues 662 to 662 by LVAGTWTSGLMSL

Name

Insertion of residues 471 to 1089 at 663 from UniProt:P16234 PDGFRA

Coordinate

663

Name

O4'-phospho-L-tyrosine at 1018

Coordinate

1018

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 572

Coordinate

572

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 574

Coordinate

574

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 720

Coordinate

720

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 731

Coordinate

731

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 742

Coordinate

742

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 754

Coordinate

754

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 762

Coordinate

762

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 768

Coordinate

768

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 988

Coordinate

988

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 849

Coordinate

849

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
glioblastoma multiforme	DOID:3068	GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme

Cross References

RefSeq

NP_002244.1

ZINC - World Drugs

VGFR2_HUMAN

Guide to Pharmacology - Targets

1813

OpenTargets

ENSG00000128052

ENSEMBL

ENST00000263923, ENSP00000263923

ZINC - FDA approved

VGFR2_HUMAN

ZINC - Substances

VGFR2_HUMAN

ZINC - Biogenic

VGFR2_HUMAN

ZINC target

P35968

PRO

P35968

GlyGen

P35968

PDB

4AGC, 4AGD, 3KVQ, 3CJG, 2P2I, 6GQQ, 3CJF, 3B8R, 2MEU, 3U6J, 3CP9, 2RL5, 4ASE, 4AG8, 6XVK, 3VHE, 2QU5, 3VNT, 3S35, 3WZD, 1Y6B, 2M59, 5EW3, 3V6B, 3VO3, 3S36, 3VID, 1VR2, 2QU6, 2X1W, 3EFL, 3DTW, 2P2H, 6GQP, 2X1X, 3VHK, 5OYJ, 3EWH, 3B8Q, 2MET, 4ASD, 1YWN, 6XVJ, 3WZE, 3CPB, 3BE2, 1Y6A, 6GQO, 3C7Q, 3S37, 3V2A, 2OH4, 3CPC, 2XIR

ZINC - Investigational

VGFR2_HUMAN

ZINC - Metabolites

VGFR2_HUMAN

HPA

ENSG00000128052-KDR

Pharos - Targets

P35968

Orphanet

KDR

ZINC - Predictions - Purchasable

VGFR2_HUMAN

HMDB Protein

HMDBP01272

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15692-4 VEGFA	1	VEGFA-165 [extracellular region] (R-HSA-4420127)	0.847	8
UniProt:P15692 VEGFA	2	VEGFA [platelet alpha granule lumen] (R-HSA-3132764) VEGFA [extracellular region] (R-HSA-2975974)	0.808	5
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.77	6
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.748	4
UniProt:P98160 HSPG2	20	HSPG2(22-4196) [extracellular region] (R-HSA-3827968) HS(4)-HSPG2 [plasma membrane] (R-HSA-2076698) HS(6)-HSPG2 [plasma membrane] (R-HSA-2076681) HS(2)-HSPG2 [plasma membrane] (R-HSA-2076659) HS(1)-HSPG2 [plasma membrane] (R-HSA-2076680) HS(3)-HSPG2 [plasma membrane] (R-HSA-2076627) HS(5)-HSPG2 [plasma membrane] (R-HSA-2076679) HSPG2(3687-4391) [extracellular region] (R-HSA-4088241) XylS-HSPG2(22-4391) [Golgi lumen] (R-HSA-2063972) Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064209) HSPG2(22-4391) [Golgi lumen] (R-HSA-2054109) Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2063971) GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen] (R-HSA-2064023) HS(3)-HSPG2 [Golgi lumen] (R-HSA-2076384) HS(4)-HSPG2 [Golgi lumen] (R-HSA-2076495) HS(2)-HSPG2 [Golgi lumen] (R-HSA-2076426) HS(1)-HSPG2 [Golgi lumen] (R-HSA-2076366) Heparan(4)-HSPG2 [Golgi lumen] (R-HSA-2076395) Heparan(3)-HSPG2 [Golgi lumen] (R-HSA-2076334) Heparan(2)-HSPG2 [Golgi lumen] (R-HSA-2076335)	0.719	5
UniProt:P35916 FLT4	2	p-Y1063,Y1230-FLT4 [plasma membrane] (R-HSA-9860553) FLT4 [plasma membrane] (R-HSA-195359)	0.702	5
UniProt:P49767 VEGFC	2	VEGFC [platelet alpha granule lumen] (R-HSA-67159) VEGFC [extracellular region] (R-HSA-139887)	0.693	6
UniProt:Q12913 PTPRJ	2	PTPRJ [specific granule membrane] (R-HSA-6799570) PTPRJ [plasma membrane] (R-HSA-6785269)	0.645	4
UniProt:O60565 GREM1	1	GREM1 [extracellular region] (R-HSA-9831023)	0.639	4
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.602	3
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.589	2
UniProt:O75340 PDCD6			0.581	4
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.573	2
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.564	2
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.564	2
UniProt:P98160-PRO_0000391622 HSPG2			0.558	2
UniProt:P98160-PRO_0000391621 HSPG2			0.558	2
UniProt:Q9MYV3-3 VEGFA			0.522	2
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.499	3
UniProt:Q14114 LRP8	2	p-Y-LRP8 [plasma membrane] (R-HSA-432136) LRP8 [plasma membrane] (R-HSA-432113)	0.471	2