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CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
Stable Identifier
R-HSA-9674572
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
Participants
components
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Homo sapiens)
p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Homo sapiens)
Participates
as an output of
p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)
as an input of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
Inferred To
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Bos taurus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Canis familiaris)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Drosophila melanogaster)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Mus musculus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane]
(Sus scrofa)
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