Reactome | p-HCK [cytosol]

p-HCK [cytosol]

Stable Identifier

R-HSA-9676060

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase HCK ecNumber2.7.10.2/ecNumber, HCK_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08631 HCK

Gene Names

HCK

Chain

initiator methionine:1, initiator methionine:, chain:2-526

Reference Genes

BioGPS Gene:3055 HCK

COSMIC (genes):HCK HCK

CTD Gene:3055 HCK

dbSNP Gene:3055 HCK

ENSEMBL:ENSG00000101336 HCK

ENSEMBL:ENSG00000101336.18 HCK

HGNC:4840 HCK

KEGG Gene (Homo sapiens):3055 HCK

Monarch:3055 HCK

NCBI Gene:3055 HCK

OMIM:142370 HCK

UCSC:P08631 HCK

Reference Transcript

Other Identifiers

11718861_a_at

16912472

2045_s_at

208018_PM_s_at

208018_s_at

3055

3881655

3881656

3881657

3881661

3881663

3881664

3881665

3881666

3881670

3881671

3881672

3881673

3881676

3881679

3881681

3881682

40742_at

8061668

A_24_P365526

GE81118

GO:0000166

GO:0001784

GO:0002376

GO:0002522

GO:0002758

GO:0002862

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005794

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005901

GO:0005925

GO:0006351

GO:0006355

GO:0006468

GO:0006887

GO:0006909

GO:0006954

GO:0007010

GO:0007155

GO:0007169

GO:0007229

GO:0007498

GO:0008284

GO:0008289

GO:0008360

GO:0009898

GO:0012501

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0023052

GO:0030133

GO:0030154

GO:0030838

GO:0031234

GO:0031410

GO:0031663

GO:0032956

GO:0035556

GO:0036211

GO:0038096

GO:0042995

GO:0043066

GO:0043226

GO:0043231

GO:0043299

GO:0045087

GO:0045728

GO:0046777

GO:0048856

GO:0048870

GO:0050727

GO:0050764

GO:0051090

GO:0051179

GO:0060333

GO:0065003

GO:0070161

GO:0071801

GO:0098542

GO:0140096

HMNXSV003043088

ILMN_1791771

M16591_s_at

PH_hs_0004996

TC20000206.hg

g4504356_3p_a_at

Participates

as a component of

Other forms of this molecule

HCK [cytosol]

Inferred To

phospho-p-HCK [cytosol] (Bos taurus)

phospho-p-HCK [cytosol] (Canis familiaris)

phospho-p-HCK [cytosol] (Danio rerio)

phospho-p-HCK [cytosol] (Gallus gallus)

phospho-p-HCK [cytosol] (Mus musculus)

phospho-p-HCK [cytosol] (Rattus norvegicus)

phospho-p-HCK [cytosol] (Sus scrofa)

Ghost homologue of p-HCK [cytosol] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001165604.1, NP_001165601.1, NP_001165600.1, NP_001165602.1, NP_002101.2

ZINC - World Drugs

HCK_HUMAN

Guide to Pharmacology - Targets

2032

OpenTargets

ENSG00000101336

ZINC - FDA approved

HCK_HUMAN

ZINC - Substances

HCK_HUMAN

ZINC target

P08631

ZINC - Biogenic

HCK_HUMAN

PRO

P08631

PDB

2OI3, 3HCK, 5HCK, 5NUH, 2C0T, 3VS7, 3REB, 5H09, 1AD5, 1BU1, 3VRZ, 3VS0, 3VRY, 2HCK, 3REA, 3VS1, 2OJ2, 2C0I, 5H0E, 3VS4, 5H0B, 1QCF, 4LUD, 3VS2, 3VS3, 5H0H, 2C0O, 4HCK, 4U5W, 3VS6, 3VS5, 3RBB, 3NHN, 8F2P, 4LUE, 5ZJ6, 5H0G, 4ORZ, 2HK5

ZINC - Investigational

HCK_HUMAN

HPA

ENSG00000101336-HCK

GeneCards

P08631

Ensembl

ENSP00000365022, ENSP00000365012, ENSP00000427757, ENST00000375852, ENST00000375862, ENSP00000429848, ENST00000629881, ENST00000518730, ENSG00000101336, ENSP00000486627, ENST00000520553

Pharos - Targets

P08631

ZINC - Predictions - Purchasable

HCK_HUMAN

HMDB Protein

HMDBP01256

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.78	4
UniProt:P27958 Genome polyprotein	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.729	5
UniProt:P42768 WAS	2	WAS [cytosol] (R-HSA-201879) p-Y291-WAS [cytosol] (R-HSA-2197668)	0.718	9
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.713	4
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.709	4
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.692	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.669	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	3
UniProt:P03407 NEF			0.646	4
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.609	2
UniProt:O92972 POLG			0.589	2
IntAct:EBI-7149158 PD1			0.558	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:P04324 NEF			0.558	2
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:P03406 NEF			0.542	2
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.527	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:P12504 VIF			0.524	3
IntAct:EBI-7355238 Q85737			0.524	3
UniProt:Q9QPN3 NEF			0.524	3
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2 [cytosol] (R-HSA-211609) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705)	0.524	2
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.524	4
UniProt:Q90VU7 Q90VU7			0.524	2
UniProt:P59046 NLRP12	5	NLRP12(241-1061) [cytosol] (R-HSA-9729690) NLRP12(1-937) [cytosol] (R-HSA-9729744) NLRP12(938-1061) [cytosol] (R-HSA-9729702) NLRP12(1-240) [cytosol] (R-HSA-9729718) NLRP12 [cytosol] (R-HSA-561195)	0.508	4

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